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The Importance of Physical Activity for Older Adults 200. Messier SP, Royer TD, Craven TE, O'Toole ML, Burns R and Ettinger WH Jr. Long-term exercise and its effect on balance in older, osteoarthritic adults: Results from the Fitness, Arthritis, and Seniors Trial FAST ; . J Amer Geriatr Soc, 48 2 ; : 131-138, 2000. 201. Ettinger WH Jr, Burns R, Messier SP, Applegate W, Rejeski WJ, Morgan T, Shumaker S, Berry MJ, O'Toole M, Monu J and Craven T. A randomized trial comparing aerobic exercise and resistance exercise with a health education program in older adults with knee osteoarthritis. The Fitness Arthritis and Seniors Trial FAST ; . JAMA, 277 1 ; : 25-31, 1997. 202. Panush RS, Schmidt C, Caldwell JR, Edwards NL, Longley S, Yonker R, Webster E, Nauman J, Stork J and Petterson H. Is running associated with degenerative joint disease? JAMA, 225: 1152-1154, 1986. Lane NE, Bloch DA, Jones HH, Marshall WH, Wood PD and Fries JF. Long-distance running, bone density, and osteoarthritis. JAMA, 255 9 ; : 11471151, 1986. 204. Aloia JF, Cohn SH, Babu T, Abesamis C, Kalici N and Ellis K. Skeletal mass and body composition in marathon runners. Metabolism, 27: 1793-1796, 1978. Nordin BEC. Clinical significance and pathogenesis of osteoporosis. Br Med J, 1: 571-576, 1971. Norris AH, Lundy T, and Shock NW. Trend in selected indices of body composition in men between the ages of 30 and 80 years. Ann N Y Acad Sci, 110: 623-639, 1963. Sidney KH, Shephard RJ and Harrison JE. Endurance training and body composition of the elderly. J Clin Nutr, 30: 326-333, 1977. Chrischilles EA, Butler CD, Davis CS and Wallace RB. A model of lifetime osteoporosis impact [published erratum appears in Arch Intern Med 1922 Mar; 152 3 ; : 655]. Arch Intern Med, 151 10 ; : 2026-2032, 1991. 209. Keene GS, Parker MJ and Pryor GA. Mortality and morbidity after hip fractures. BMJ, 307 6914 ; : 12481250, 1993. 210. Watts NB. Postmenopausal osteoporosis. Obstet Gynecol Surv, 54 8 ; : 532-538, 1999. 211. Burge RT, Worley DJ, King AB. The cost of osteoporosis in Michigan: Projections for 2000 2025. Proctor & Gamble Pharmaceuticals, September 26, 2000 212. Meiner SE. An expanding landscape. Osteoporosis. Treatment options today. Adv Nurse Pract, 7 ; : 2631, 1999. 213. Sinaki M. Musculoskeletal challenges of osteoporosis. Aging Milano ; , 10 3 ; : 249-262, 1998. 214. Henderson NK, White CP and Eisman JA. The roles of exercise and fall risk reduction in the prevention of osteoporosis. Endocrinol Metab Clin North Am, 27 2 ; : 369-387, 1998. 215. Layne JE and Nelson ME. The effects of progressive resistance training on bone density: A review. Med Sci Sports Exerc, 31 1 ; : 25-30, 1999. 216. Smith EL, Reddan W and Smith PE. Physical activity and calcium modalities for bone mineral increase in aged women. Med Sci Sports Exer, 13: 60-64, 1981. Aloia JF, Cohn SH, Ostuni JA, Lane R and Ellis K. Prevention of involutional bone loss by exercise. Ann Intern Med, 89: 356-358, 1978. Krolner B, Toft B, Nielsen SP and Tondevold E. Physical exercise as prophylaxis against involutional vertebral bone loss: A controlled trial. Clin Sci, 64: 541-546, 1983. Smith EL Jr, Smith PE, Ensign CJ and Shea MM. Bone involution decrease in exercising middle-aged women. Calif Tissue Int, 36: S129-S138, 1984. 220. Kronhed AC and Moller M. Effects of physical exercise on bone mass, balance skill, and aerobic capacity in women and men with low bone mineral density, after one year of trainingA prospective study. Scand J Med Sci Sports, 8 5 Pt 1 ; 290-298, 1998. 221. Preisinger E, Alacamlioglu Y, Pils K, Saradeth T and Schneider B. Therapeutic exercise in the prevention of bone loss. A controlled trial with women after menopause. J Phys Med Rehab, 74 2 ; : 120-3, 1995. 222. Nelson ME, Fiatarone MA, Morganti CM, Trice I, Greenberg RA and Evans WJ. Effects of highintensity strength training on multiple risk factors for osteoporotic fractures. A randomized controlled trial. JAMA, 272 24 ; : 1909-14, 1994. 223. Pollock ML, Garzarella L, Graves JE, Carpenter DM, Legett S II, Fulton MN, Foster, Tucci J, Mananguil R. Effects of isolated lumbar extension resistance training on bone mineral density of the elderly. Med Sci Sports Exer, 24: S66, 1992. 224. Menkes A, Mazel S, Redmond RA, Koffler K, Libanati CR, Gundberg CM, Zizic TM, Hagberg JM, Pratley RE and Hurley BF. Strength training increases regional bone mineral density and bone remodeling in middle-aged and older men. J Appl Physiol, 74: 2487-2484, 1993. Lundt M, Felsenberg D, Reeve J, Benevolenskaya L, Cannata J, Dequeker J, Dodenhof C, Falch JA, Masaryk P, Pols HA, Poor G, Reid DM, Scheitd-Nave C, Weber K, Varlow J, Kanis JA, O'Neill TW and Silman AJ. Bone density variation and its effects on Michigan Governor's Council on Physical Fitness, Health and Sports and zestoretic, for example, brinzolamide.

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Our strategy of driving growth in our in-line medicines and investing in promising new medicines is the essence of the new Pfizer. We will continue to focus on enhancing value for our shareholders and meeting patients' needs worldwide." Dr. McKinnell said there were two primary drivers for Pfizer's better-than-expected performance in the quarter: better revenue performance in the Human Health business; and operating expense savings, coupled with the acceleration of the "Adapting to Scale" AtS ; cost savings to $800 million in 2005, which is double the goal for the year. "While we are pleased that Pfizer's performance in 2005 exceeded previous expectations, investors should be aware that the factors driving Pfizer's performance may differ materially in 2006, " Dr. McKinnell added. "We look forward to providing a full briefing on our 2006 financial guidance, strategy, products, and pipeline at our analyst meeting in New York on February 10. We enter the new year with renewed determination to capitalize on all the opportunities we see to bring our innovative medicines to those who need them." Portfolio, Pipeline Position Human Health for Future Success "2005 has been a challenging year for Pfizer Human Health, " said Karen Katen, vice chairman of Pfizer Inc and president of Pfizer Human Health. "However, fourth-quarter and full-year 2005 results indicate that we are well-positioned for the future, with a solid in-line portfolio and a rich pipeline of innovative new medicines." Loss of exclusivity in the U.S. of certain key medicines, uncertainty related to Celebrex, and the suspension of Bextra sales cumulatively reduced 2005 worldwide revenue by $5.7 billion. As a result, total Pfizer Human Health revenue declined $1.8 billion, or 4 percent, for full-year 2005 compared to full-year 2004. In the U.S., Human Health revenue declined 12 percent for the full-year 2005 compared to the same period in 2004. Excluding the major medicines that lost exclusivity in the U.S. in 2004 and 2005 and the selective COX-2 inhibitors, Human Health adjusted revenues 2 ; grew 11 percent worldwide and 10 percent in the U.S. for full-year 2005 compared to 2004. The successful launches of seven new medicines over the past two years are enabling Pfizer to replenish our portfolio. The combined sales of these products Inspra, Caduet, Olmetec, Macugen, Revatio, Zmax, and Lyrica ; generated $284 million in fourth-quarter 2005 revenue and $632 million in full-year 2005 revenue worldwide. Many of Pfizer's top medicines achieved double-digit growth worldwide in 2005 compared to 2004 across many therapeutic areas, including cardiovascular metabolic diseases Lipitor up 12 percent, Caduet up 272 percent central nervous system disorders Geodon up 26 percent, Relpax up 38 percent infectious and respiratory diseases Zyvox up 33 percent, Vfend up 38 percent oncology Aromasin up 73 percent and ophthalmology Xalatsn Xalacom up 12 percent. 3. Surcel, H. M., Troye-Blomberg, M., Paulie, S., Andersson, G., Moreno, C., Pasvol, G., Ivanyi, J. 1994 ; Th1 Th2 profiles in tuberculosis, based on the proliferation and cytokine response of blood lymphocytes to mycobacterial antigens. Immunology 81, 171176. 4. Tani, K., Murphy, W. J., Chertov, O., Salcedo, R., Koh, C. Y., Utsunomiya, I., Funakoshi, S., Asai, O., Herrmann, S. H., Wang, J. M., Kwak, L. M., Oppenheim, J. J. 2000 ; Defensins act as potent adjuvants that promote cellular and humoral immune responses in mice to a lymphoma idiotype and carrier antigens. Int. Immunol. 12, 691700. 5. Bonecchi, R., Bianchi, G., Bordignon, P. P., D'Ambrosio, D., Lang, R., Borsatti, A., Sozzani, S., Allavena, P., Gray, P. A., Mantovani, A., Sinigaglia, F. 1998 ; Differential expression of chemokine receptors and chemotactic responsiveness of type 1 T helper cells Th1s ; and Th2s. J. Exp. Med. 187, 129 134. Sallusto, F., Lenig, D., Mackay, C. R., Lanzavecchia, A. 1998 ; Flexible programs of chemokine receptor expression on human polarized T helper 1 and 2 lymphocytes. J. Exp. Med. 187, 875 883. Imai, T., Baba, M., Nishimura, M., Kakizaki, M., Takagi, S., Yoshie, O. 1997 ; The T cell-directed CC chemokine TARC is a highly specific biological ligand for a CC chemokine receptor 4. J. Biol. Chem. 272, 15036 15042. Imai, T., Chantry, D., Raport, C. J., Wood, C. L., Nishimura, M., Godiska, R., Yoshie, O. 1998 ; Macrophage-derived chemokine is a functional ligand for the CC chemokine receptor 4. J. Biol. Chem. 273, 1764 1768. Imai, T., Nagira, M., Takagi, S., Kakizaki, M., Nishimura, M., Wang, J., Gray, P. W., Matsushima, K., Yoshie, O. 1999 ; Selective recruitment of CCR4-bearing Th2 cells toward antigen-presenting cells by the CC chemokines thymus and activation-regulated chemokine and macrophagederived chemokine. Int. Immunol. 11, 81 88. Snapper, C. M., Mond, J. J. 1993 ; Towards a comprehensive view of immunoglobulin class switching. Immunol. Today 14, 1517. 11. Goldman, M., Druet, P., Gleichmann, E. 1991 ; Th2 cells in systemic autoimmunity: insights from allogeneic diseases and chemically-induced autoimmunity. Immunol. Today 12, 223227. 12. Akahoshi, M., Nakashima, H., Tanaka, Y., Kohsaka, T., Nagano, S., Ohgami, E., Arinobu, Y., Yamaoka, K., Niiro, H., Shinozaki, M., Hirakata, H., Hariuchi, T., Otsuka, T., Niho, Y. 1999 ; Th1 Th2 balance of peripheral T helper cells in systemic lupus erythematosus. Arthritis Rheum. 42, 1644 1648. Horwitz, D. A., Gray, J. D., Behrendsen, S. C., Kubin, M., Rengaraju, M., Ohtsuka, K., Trinchieri, G. 1998 ; Decreased production of interleukin-12 and other Th1-type cytokines in patients with recent-onset systemic lupus erythematosus. Arthritis Rheum. 41, 838 844. Takahashi, S., Fossati, L., Iwamoto, M., Merino, R., Motta, R., Kobayakawa, T., Izui, S. 1996 ; Imbalance towards Th1 predominance is associated with acceleration of lupus-like autoimmune syndrome in MRL mice. J. Clin. Investig. 97, 15971604. 15. Segal, R., Bermas, B. L., Dayan, M., Kalush, F., Shearer, G. M., Mozes, E. 1997 ; Kinetics of cytokine production in experimental systemic lupus erythematosus: involvement of T helper cell 1 T helper cell 2-type cytokines in disease. J. Immunol. 158, 3009 3016. Tan, E. M., Cohen, A. S., Fries, J. F., Masai, A. T., McShane, D. J., Rothfield, N. F., Schaller, J. G., Talal, N., Winchester, R. J. 1982 ; The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum. 25, 12711277. 17. Bombardier, C., Gladman, D. D., Urowitz, M. B., Caron, D., Chang, C. H. 1992 ; Committee on prognosis studies in SLE. Derivation of the SLEDAI. Arthritis Rheum. 35, 630 640. Sone, S., Yanagawa, H., Nishioka, Y., Orino, E., Bhaskaran, G., Ogura, T., Nii, A., Mizuno, K., Heike, Y., Ogushi, F. 1992 ; Interleukin-4 as a potent down-regulator for human alveolar macrophages capable of production tumor necrosis factor-alpha and interleukin-1. Eur. Respir. J. 5, 174 181. Yamamoto, J., Adachi, Y., Onoue, Y., Adachi, Y. S., Okabe, Y., Itazawa, T., Toyoda, M., Seki, T., Morohashi, M., Matsushima, K., Miyawaki, T. 2000 ; Differential expression of the chemokine receptors by the Th1- and Th2-type effector populations within circulating CD4 T cells. J. Leukoc. Biol. 68, 568 574. Nagata, K., Tanaka, K., Ogawa, K., Kemmotsu, K., Imai, T., Yoshie, O., Abe, H., Tada, K., Nakamura, M., Sugamura, K., Takano, S. 1999 ; Selective expression of a novel surface molecule by human Th2 cells in vivo. J. Immunol. 162, 1278 1286. Cosmi, L., Annunziato, F., Iwasaki, M., Galli, G., Manetti, R., Maggi, E., Ngata, K., Romagnani, S. 2000 ; CRTH2 is the most reliable marker for the detection of circulating human type 2 Th and type 2 T cytotoxic cells in health and disease. Eur. J. Immunol. 30, 29722979. 22. Llorente, L., Richaud-Patinm, Y., Wijdenes, J., Alcocer-Varela, J., Maillot, M. C., Durand-Gasselin, I., Fourrier, B. M., Galanaud, D., Emilie, D. 1993 ; Spontaneous production of interleukin-10 by B lymphocytes and monocytes in systemic lupus erythematosus. Eur. Cytokine Netw. 4, 421 427 and zithromax. BACKGROUND: First introduced in 2000 passed by the House but not taken up by the Senate ; , this measure defines the words "person, " "human being, " "child, " and "individual" to include "every infant member of the species homo sapiens who is born alive at any stage of development." The term "born alive" is defined as "the complete expulsion or extraction" at any stage of development of the infant member who "breaths or has a beating heart, pulsation of the umbilical cord, or definite movement of voluntary muscles, regardless of whether the umbilical cord has been cut, and regardless of whether the expulsion or extraction occurs as a result of natural or induced labor, cesarean section, or induced abortion." This legislation ensures that all infants who are born alive are treated as persons for purposes of federal law. HOUSE: On June 14, 2001, Rep. Steve Chabot R-OH ; introduced the Born-Alive Infants Protection Act of 2001 H.R. 2175 ; . The bill has 105 cosponsors and was referred to the Judiciary Subcommittee on the Constitution. On July 12, a subcommittee hearing was held. Immediately the bill was marked up and approved. On July 24, the bill was marked up in full committee and approved, 25-yes, 2-no. On August 2, the bill was reported from committee H. Rept. 107-186 ; and placed on the House calendar. The text of H.R. 2175 also was added to the Bipartisan Patient Protection Act H.R. 2563 ; and was part of that bill as it passed the House on August 2. On September 6, H.R. 2563 was read the second time and placed on the Senate calendar. SENATE: On June 14, 2001, Sen. Rick Santorum R-PA ; also introduced the Born-Alive Infants Protection Act S. 1050 ; into the Senate. This measure had six cosponsors and was referred to the Judiciary Committee. The Senate bill was attached as Senate Amendment 814 to the Patients' Bill of Rights S. 1052 ; . On June 29, Senate Amendment 814 was approved, 98-yes, 0-no Roll Call 208 ; . Thereafter S. 1052 was approved. CONFERENCE COMMITTEE: H.R. 2563 and S. 1052 await action in conference committee. STATUS: The Born-Alive Infants Protection Act is a part of the health care reform bills H.R. 2563 and S. 1052 ; that passed the House and Senate and await action in conference committee. H.R. 2175 has been placed on the House calendar, for instance, trusopt. Examples of these are xalatan, travatan, rescula and lumigan and zocor!

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