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Nmol L ; , whereas viral replication measured by p24 production in culture supernatants ; was suppressed by 90% at drug concentrations ranging from 30 to 300 nmol L to 1000 nmol L. Data from 3 representative patients patients A, B, and C, respectively ; are shown in Figure 3. Phenotype analysis of patients' PBMCs at the end of the culture period revealed that both CD4 and CD8 T cells were equally expanded under either of the 2 PIs data not shown ; . In 15 HAART-treated patients 5 virologic responders, 5 transient responders, and 5 nonresponders ; , effective concentrations of PIs enhancing T-cell survival and suppressing viral replication were further evaluated in vitro. In the presence of either of the 2 PIs, survival was increased in all patients' PBMCs tested; this occurred independently of their patterns of virologic response to HAART. The range of effective doses 1-3 log10 ; was inversely correlated with the CD4 cell count P .004 ; . On the other hand, viral replication was detected in 1 of virologic responders, 4 of 5 transient responders, and all 5 nonresponders. Among p24-positive cultures, the effective dose for 90% viral inhibition was high 214 nmol L or 169 nmol L for indinavir or saquinavir ; in 2 of, for instance, zyrtec d side effects.
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