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To allow for out-patient administration. This dosing can be reviewed in: Blood. 2004; 104: 1437. Title: Randomized, double-blind, activecontrolled trial of every-3-week darbepoetin alfa ARANESP ; for the treatment of chemotherapyinduced anemia Authors: Canon J-L, Vansteenkiste J, Bodoky G, et al. Reference: J Natl Cancer Inst. 2006; 98: 273-284. Purpose: Anemia is a frequent complication of cancer treatment and effects patient's quality of life. Darbepoetin is a long-acting erythropoiesis-stimulating protein that is administered by a variety of different schedules. This study compares the efficacy and safety of weekly versus an every-3-week regimen. Methods: Patients with a diagnosis of a nonmyeloid malignancy, undergoing at least 12 weeks of cytotoxic chemotherapy and were anemic hemoglobin [Hbg] 11 g dL ; within 24 hours of randomization, were eligible for the study. Patients were randomly assigned in a 1: ratio to receive darbepoetin alfa at a fixed dose of 500 mcg every 3 weeks or a weight-based dose of 2.25 mcg kg weekly for 15 weeks. All injections were administered subcutaneously. Doses of the drug were held if the Hbg 13 g dL the Hbg concentration increased by 1 g greater over a 14-day period. When the Hbg dropped to 12 g dL, the study drug was decreased to 60% of and accolate.

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