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Information can create a sort of bandwagon effect, leading people to think that it will be good for them because it has been good for many people. We can then see some applications of the fallacy of relevance. In particular, in what sense is the claim that `Zoloft is number one prescribed by physicians' relevant in a context where the intention claimed by the pharmaceutical industry is to provide accurate information for making good health decisions? There is no causal link between the fact that a medicine is most prescribed and its quality. Prescription could, in fact, be driven by other factors. Again, turning to the Allegra180mg ad, the product is presented as a medicine that lasts four times longer than other similar brands, as if this was the most relevant characteristic. As we said before, Allegra180mg is restricted in its use because it is a strong medicine. We thus wonder whether putting so much emphasis on its comparative qualities, and leaving the indications about when and for whom it is not recommended in the back page of the ad - written in a rather unreadable format - is really an adequate communication strategy for orienting in the right direction the hearer's expectations of relevance Sperger & Wilson 1995.

N Shanklanda, W I F Davidb, K Shanklandb, A Kennedyc, C S Framptond and A Florencea Department of Pharmaceutical Sciences, University of Strathclyde, Glasgow, G4 0NR, UK E-mail: n.shankland strath.ac b ISIS Facility, Rutherford Appleton Laboratory, Chilton, Didcot, Oxon., OX11 0QX, UK c Department of Pure and Applied Chemistry, University of Strathclyde, Glasgow, G1 1XL, UK d Roche Discovery Welwyn, Welwyn Garden City, Herts., AL7 3AY, UK INTRODUCTION The active ingredients that are used in the formulation of medicinal products are widely manufactured in the form of polycrystalline powders. The existence of different crystalline both polymorphs and solvates ; and amorphous forms of these materials can have significant effects upon the processing, manufacture and stability of medicinal products. Moreover, new forms can often appear unpredictably in batches of raw materials. Clearly, the physical and chemical properties of a pharmaceutical compound are correlated with its crystal structure and so a detailed crystallographic understanding of these materials is important. One topic of particular interest is the reversible transformation between hydrated and anhydrous forms, especially where the transformation is associated with unwanted changes in chemical and physical properties. The starting point for this study is a dihydrate of zopiclone Fig. 1 ; , a non-benzodiazepine hypnotic drug used in the treatment of insomnia. The stimulus for our investigation was this: knowing that the compound exists in more than one crystalline modification, one of which is a dihydrate, could we determine the crystal structure of the anhydrous material produced on heating the dihydrate? If so, might we be able to observe a relationship between the two structures and thus gain some insight into the structural mechanism of the transformation? and zyprexa.
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Quantitative Aggregation Table 3 shows the number of trials with positive results among all trials and high-quality trials for different classes of agents; it includes only agents for which there was more than one trial. The number of trials that showed an improvement in any outcome global or specific symptoms ; is displayed, along with the subset of trials that showed global improvement alone. Because specific symptoms assessed and measures used among the different studies varied considerably, global improvement was viewed as a common metric across treatments.
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Analyzed statistically. Bacteriology. Routine standard microbiological methods for culture of clinical specimens were used during the trial 13 ; . In vitro antimicrobial susceptibility to the study drugs was determined by the modified Bauer-Kirby disk diffusion method 1, 14 ; . Statistical analysis. Study data were analyzed by the SPSS and Epistat programs by using the chi-square or Fisher exact tests for categorical variables and the unpaired Student t test for continuous variables. The level of significance was taken.

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