More new drugs for the treatment of insomnia are currently being developed, indiplon will be launched later this year in both immediate and extended-release formations.
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The Council may recognize specialized divisions of the Society so as to encourage communication among members with special interests in pharmacology. Any Division so recognized shall be open to any interested member of the Society. Functions and activities of Divisions shall be subject to supervision by the Council.
Policy, through public Interest litigation, it was revealed that some of the largest Pharmaceutical companies had highly overcharged some of their bulk drugs. Thereafter, a large number of companies were found to be over changing for both bulk drugs and formulations. The Supreme Court directed the governmental to recover this excess profit from the drug companies, amounting to Rs.20 million in 1987, and deposit the same to a Drug Prices Equalizing Account DPEA ; . Some of the drug companies started paying partly to government, others simply killed time and then refused to pay. One of the well known MNC, in their balance sheet of 1993, had earmarked nearly Rs.50 million to pay back the government and managed tax relief but never paid anything to the government thereafter. Complaints and cases poured in continuously on the violation of the order. Numerous Government initiative were announced to review the entire matter of recoveries from drug companies in DPEA". But since then nothing has been done in recovering this excess illegal profit which the government terms as "unintended profit". The point then remains unanswered is that when the drug companies were found distinctively overcharging certain drugs and the Supreme Court had ordered recovery of the excess profit, the Government could have at least asked for reduction of prices of these drugs. Instead steady rise of prices was allowed. This has set up a runaway reaction in flouting price control orders. Drug Price Control in India Formulations The industry has repeatedly made petitions that the formula for price control in DPCO has been faulty and companies have incurred loss due to this process of calculation. The formula for retail price RP ; can be examined in the following manner: RP RM + MAPE 100 ; Where: RM Raw material cost Packing material cost PC Packing cost CC Conversion cost Maximum allowable post Manufacturing Expenses MAPE ; now being 100 RP RM + 100 + 100 ; i.e. RP RM + The above calculation shows that in the event of increase of RM, PM, PC OR CC, by a single unit, the drug companies are allowed to charge twice to that. In each drug policy large concessions have been given to the drug industry by knocking out more drugs from the price control basket. Following the 1994 DPCO announcement nearly all drugs released from the basket underwent immediate price rise and the hikes in many cases were phenomenally high- sometimes as much as 200% to 300%. The Government's statement in this respect was "During the five months period of September 1995 to February 1996 the increase of wholesale prices 1981-82 base ; shows an increase of 0.4% of all commodities". The stated 0.4% rise in index does in no way reflect the real increase. A study of over 820 brands in different therapeutic categories was made and the results have been captured in a CDMU Documentation Center database. Prices here were, for instance, quinapril 10 mg.
Dropped from 1, 157 in 1968, to 448 in 1980, to 308 in 1990, to 187 in 1999, and to 148 in 2002. See DEP'T OF HEALTH & HUMAN SERVS., CENTERS FOR DISEASE CONTROL & PREVENTION, NAT'L INST. FOR OCCUPATIONAL SAFETY & HEALTH, WORKER HEALTH CHARTBOOK, 2004 169 Pub. No. 2004-146, Sept. 2004 ; , available at : cdc. gov niosh docs chartbook ; Dep't of Health & Human Servs., Centers for Disease Control & Prevention, Silicosis Mortality, Prevention, and Control -- United States, 1968-2002, MMWR WKLY., Apr. 29, 2005, at 1, available at : cdc.gov mmwr preview mmwrhtml mm5416a2 , printed in 29: 21 J. AM. MED. ASS'N 2585 June 1, 2005 ; . A recent study by federal Occupational Safety & Health Administration staff found that "a downward trend in the airborne silica exposure levels was observed during 19882003." A.S.Yassin et al., Occupational Exposure to Crystalline Silica Dust in the United States, 1988-2003, 113 ENVTL. HEALTH PERSPECTIVES 3255, Mar. 1, 2005 ; . In Silica Prods. Liab. Litig., 2005 WL 1593936, at * 5; see also Mike Tolson, Attorneys Behind Silicosis Suits Draw U.S. Judge'sWrath; Houston Legal Firm Fined; Order From Bench Says Diagnoses Made for the Money, HOUSTON CHRON., July 2, 2005, at A1; Editorial, The Silicosis Sheriff, WALL ST. J., July 14, 2005, at A10. A federal grand jury has been convened in Manhattan to consider possible criminal charges arising out of the federal silica litigation. See Jonathan D. Glater, Civil Suits Over Silica In Texas Become a Criminal Matter in NewYork, N.Y. TIMES, May 18, 2005, at C5; Editorial, Silicosis, Inc., WALL ST. J., Oct. 27, 2005, at A20 supporting Justice Department probe of asbestos and silica suits ; . Jonathan D. Glater, The TortWars, at a Turning Point, N.Y. TIMES, Oct. 9, 2005, at C1. See Jonathan D. Glater, Lawyers Challenged on Asbestos, N.Y. TIMES, July 20, 2005, at C1. See Jonathan D. Glater, Civil Suits Over Silica in Texas Become a Criminal Matter in NewYork, N.Y. TIMES, May 18, 2005, at C5. See Press Release, Barton, Whitfield Query Physicians Regarding Silicosis, Aug. 2, 2005, at : energycommerce.house.gov 108 News 08022005 1619 . In Silica Prods. Liab. Litig., 2005 WL 1593936, at * 5. See The Kerry-Edwards Plan: A Stronger America Through More Affordable Health Care, at : johnkerry issues health care kit plan kerry in support of "preventing and punishing frivolous lawsuits by putting in place tough, mandatory sanctions, including a `three strikes and you're out' provision that forbids lawyers who file three frivolous cases from bringing another suit for the next 10 years" Transcript of Vice Presidential Debate, Oct. 5, 2004 in which Vice Presidential Candidate John Edwards stated "have a three-strikes.
Not to export their cars to the United States for a "windfall profit." Chrysler stated that it would stop honouring warranties in the United States on vehicles originally sold in Canada as of the 2003 model year. The struggle between automobile manufacturers and automobile exporters, broadly similar to that in the pharmaceutical trade, resulted in the exporters' launching an anti-trust lawsuit against the manufacturers in the United States in February 2003 Graham 2002a and references; Keenan 2003 ; . It is important to recognize this macroeconomic factor because there are no price controls in Canada's automobile market, which implies that, even if the American and Canadian pharmaceutical markets were free markets, price differences would exist. There is, however, also government intervention in prices in Canada's prescription drug market. The PMPRB is the national, quasi-judicial, body that regulates manufacturers' prices of patented drugs but does not purchase drugs.1 Governments are also bigger buyers of prescription drugs in Canada than in the United States. Although private insurance and out-of-pocket payments by patients make up the slight majority of prescription expenditures, government drug benefit plans primarily financed and managed by the provinces ; pay for 45% of Canada's prescription drugs for outpatients CIHI 2003: 66 ; . Proportionally, this is about twice as much as in the United States CMS 2003: Table 3 and
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I routinely encounter patients who offer suggestions regarding their treatment regimen. This is usually prompted by a conversation with another individual with Parkinson disease who has experienced "wonderful results" with their own treatment. There seems to be a lot of confusion over why a specific drug regimen is employed and how the choice is made. This is complicated by the fact that pharmaceutical companies frequently make claims for their products which appear in the press or are included in news stories about recent publications in the medical literature. Some patients become impatient with the process of "trying a different medication" and seem to feel that a universal "cookbook" for treating patients with Parkinson disease should be utilized. While covering all the controversies in therapy is beyond the scope of this article, some major points are worth reviewing. doing and the importance of these activities to the individual. In many patients symptom progression is very slow, a fact which often seems to be overlooked. Avoiding immediate treatment delays long-term side effects which might interfere with therapy many years later.
In a preferred embodiment, the process comprises the steps of contacting quinapril hcl with a suitable amount of a stabilizer consisting essentially of magnesium oxide and one or more saccharides to form a mixture; and subjecting the mixture to wet granulation processing and perindopril.
Hysicians have several options when choosing a billing system. Two of the most popular options are buying software and contracting with a billing service. Here are the advantages and disadvantages of these options. The first method is buying and maintaining software for billing and reimbursement. This method requires an initial investment in software that can be significant and is likely to require ongoing maintenance and upgrade fees. Although some of these systems provide support for collecting from insurers, most do not, and so most of these systems would require the practice to incur costs for staff payroll and benefits. The practice still has to invest in forms, office supplies, postage, and telephone and office costs as well. These systems mean keeping up with changes in billing codes and coverage restrictions. The initial investment can be well over $100, 000, depending on the size of the practice. Typical collection success rates range from 70% to 90%. The advantages of such a system are that the physician has 100% control since the practice owns the software. The disadvantages include a high capital investment, challenges involving staff training, the need for software updates, and a focus on billing but not necessarily on collections. Also, such software does not support the practice in adopting industry best practices, typically has poor reporting capabilities, and the reimbursement rates are frequently lower than they are with other options. The second method involves contracting with a billing service. Claims are submitted using off-the-shelf billing software and staff manually follow up on late payers and denials. Costs range from 6% to 15% of collections depending on volume and specialty, and collection rates range from 70% to 90%. The advantages of contracting with a billing service are a minimal capital investment, fewer back-office employees, and access to billing expertise and experience through the service's staff. The disadvantages include a loss of control since much of the billing work is done off site, and a focus on billing but not necessarily on collections. no additional costs for software. The newly affiliated physicians would simply access the practice's records as the other physicians do: via the Internet. In today's health care environment, forming a mega-group can make sense for many physicians. With a sound yet flexible structure, a mega-group will adapt to the changing trends in health care. The next step, partnering with a management company that continually invests in processes and technology, will help reduce administrative and financial problems, improve collections, and increase profit.
Osteoporosis ask the expert osteoporosis ask the expert questions this month have been answered by: wayne whitted h obgyn osteoporosis, editorial advisor paul burstein facog obgyn osteoporosis, editorial advisor q: can osteopenia be reversed without drugs and sumycin.
There is evidence that active participation in artwork can engender redemptive self-respect in those who feel excluded from society. This may be the result of gaining admittance to an activity that enjoys social and cultural prestige. But it seems also to reflect that standards of achievement in art are internal and self-judged, and allow for a sense of personal fulfilment . Extract from What Good are the Arts? by John Carey ; Deciding whether to engage in arts and culture can be difficult for some people. Perhaps they compare it to looking at a blank canvas or falling asleep at the opera? However, as Carey has identified, involvement in the arts has shown marked improvements in health, wellbeing, self-esteem and, ultimately, feeling valued within our society. Twenty per cent of the population or an alarming one in five people have difficulty fully experiencing and participating in arts activities and events. As the population ages and more people acquire a disability, access, participation and experience is projected to become an even bigger issue. Accessible Arts is the peak arts and disability advocacy body in NSW which provides opportunities for people with varying abilities to express themselves creatively. Changing attitudes, developing a model for the future and refreshing public knowledge about these issues is where Accessible Arts leads the way. The organisation acts as a consultant to other cultural organisations, helping to make their events more accessible and enjoyable for all people. The vibrant and rewarding experience of taking a tactile tour at the Art Gallery of NSW or a person who is blind having a performance at the Sydney Theatre Company described to them in words can make all the difference to individuals and communities that experience barriers. Accessible Arts regularly provides up-to-date information on accessible events and activities, an arts tutor list, arts resources, a library, funding information, room hire, training and volunteering opportunities. Accessible Arts also offers a low-cost half-day TAFEaccredited Disability Awareness and Access Training course that helps to identify barriers faced by people with disabilities. The course looks at accessing venues and participating in events, and suggests ways of breaking down physical and attitudinal barriers. Accessible Arts also celebrates how people with disabilities are involved in the arts via their monthly newsletter. They are keen to hear from people who have created an original artwork, poem, short story, played music or participated in a cultural activity. For more information or to subscribe to the monthly Accessible Arts e-newsletter, contact Nadia de Ceglie on 02 9251 6499, email: ndeceglie aarts .au or visit the website at aarts .au. OUR VISION A society in which people with disabilities fully experience and participate in the arts and cultural life.
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By Bob Smith In 1946 a young student of the School of Pharmacy at Purdue University, despondent over a less than perfect grade on a test, took a dose of strychnine and died. She knew how her body would react to the lethal cocktail so she found a secluded spot near the air port and tied herself to a tree. Every pharmacy student has studied strychnine and its effects on living animals. In laboratory settings you have seen the runaway nerve impulses that cause every muscle in the body to contract, at the same time. The result is a horrible, twisting, spasm producing, often bone breaking and strangling death. Until the late 1960's strychnine was sold in Drug Stores on demand and after the customer signed the Violent Poison.
FC111 Fluorescence lifetime imaging of photosensitizer metabolites using ps diode lasers and in laser scanning microscopes A. Rueck, F. Dolp, E. Haseroth, C. Scalfi-Happ; ILM, Ulm, Germany. A setup consisting on a laser scanning microscope Zeiss, Germany ; equipped with appropriate detection units was developed for fluorescence lifetime imaging FLIM ; for on-line detection of structural changes of various biomolecules. Short-pulsed excitation was performed with diode lasers which emit pulses at 398 nm and 440 nm with 70 ps pulse duration PicoQuant, Germany ; . The laser diodes were coupled to the laser scanning microscope via external coupling units and appropriate beam splitters. An ultrafast photomultiplier was used together with a time-correlated single photon counting module TCSPC ; SPC-730, Becker & Hickl, Germany ; to determine the fluorescence lifetime of different metabolites of photosensitizers with subcellular resolution and to record lifetime images t-mapping ; 1 ; . Especially, we will discuss the time-resolved fluorescence characteristics of 5-ALA 5-aminolevulinicacid ; induced protoporphyrine IX PPIX ; and other metabolites as well as the lipophilic derivative 5-ALAhe 5-aminolevulinicacid hexylester ; . In principal three different lifetime regions could be observed in the cells. Regions, correlated with lifetimes around 10 and 12 ns were found in the mitochondria and plasma membrane of the cells and attributed to PPIX, wherease a lifetime around 6 ns possibly coincides with other metabolites. In the case of 5-ALAhe the lifetime of PPIX was even longer, which could be due to different subcellular localization. During illumination the component with the longer lifetime completely vanished, whereas the shorter lifetime was retained. Because the photodynamic effects can be correlated with the lifetime of the excited states it seems that FLIM, using ps diode lasers and TCSPC is a valuable method to selectively identify and localize the photodynamically active photosensitizer. 1 ; M. Kress, Th. Meier, R. Steiner, F. Dolp, R. Erdmann, U. Ortmann, and A. Rueck Time-resolved microspectrofluorometry and fluorescence lifetime imaging of photosensitizers using ps pulsed diode lasers in laser scanning microscopes Journal of Biomedical Optics 8 1 ; : 2632 2003 and salmeterol.
When compared with first-generation antipsychotics, second-generation antipsychotics improve medication-adherence behavior, quality of life, and subjective tolerability. Most published studies on secondgeneration antipsychotics have dealt with issues related to efficacy and safety, but not quality of life. Few studies have focused on effectiveness in terms of such important outcomes as medication-adherence behavior, quality of life, subjective tolerability, and overall satisfaction with treatment. Welldesigned, controlled, and adequately powered studies are urgently needed before any firm conclusions can be reached, because pregnancy.
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These measures can also be used to contain direct consumer expenditure. In developing countries, up to 90% of drugs are paid "out of pocket", representing the largest household health expenditure in these countries. Manufacturers' selling prices can be contained through competition, volume purchasing, and price controls. Competition among therapeutically similar patented drugs can bring down prices. This effect is beginning to be seen even among HIV drugs. But measures to reduce manufacturers' prices can only be part of the strategy. While in developed countries, manufacturers' prices typically represent 50 60% of the final consumer price, in developing countries the manufacturers' selling price can be as little as 20% of that finally paid by the consumer with up to 80% of the price consisting of import duties, taxes, distribution costs, and dispensing fees. WHO supports the reduction or even elimination of import duties for pharmaceuticals. Equally, a reduction of national and local taxes needs to be negotiated and reasonable levels of distribution and dispensing mark-ups sought. A number of countries are moving to a system of fixed professional dispensing fees which reduces the incentive for the pharmacist or drug seller to dispense higher cost products. Price information for health professionals and consumers is essential for making an informed choice and
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Mr. Brazier, HON. B. COMM., joined DRAXIS in August 1998 as President of SpectroPharm Dermatology and now holds the position of President of DRAXIS Pharmaceutica. Prior to joining the Company, Mr. Brazier was the Director of Skin Care at Allergan Inc. Mr. Brazier also held positions in Marketing Management and Sales Management in his 10 years with Allergan. From 1980-1989, Mr. Brazier held Marketing and Sales positions with Bausch & Lomb, Stafford Foods and Canada Packers. Mr. Brazier holds an Honors B. Comm., majoring in Marketing and Finance. Jack A. Carter Toronto, ON Officer since September 1998. Officer, because quinaprli used for.
ANTINEOPLASTIC AND IMMUNOSUPPRESANTS All oral antineoplastic and immunosuppressant agents are covered under the prescription benefit if FDA approved. MISCELLANEOUS $$$$ interferon alpha-2b INTRON A KIT PA ; interferon alpha-2a ROFERON A KIT PA ; $$$$ $$$$ peg interferon alpha-2b PEG-INTRON PA ; $$$$ peg interferon alpha-2a PEGASYS PA ; --BLOOD MODIFIERS-ANTICOAGULANTS warfarin * COUMADIN NTI ; enoxaparin LOVENOX PA ; PLATELET AGGREGATION INHIBITORS cilostazol PLETAL PA ; clopidogrel * PLAVIX PA ; PA if days supply 30 dipyridamole ext. rel. aspirin AGGRENOX PA ; MISCELLANEOUS epoetin alfa PROCRIT PA ; epoetin alfa EPOGEN PA ; filgrastim G-CSF NEUPOGEN PA ; phytonadione MEPHYTON aminocaproic acid * AMICAR CARDIOVASCULAR ACE INHIBITORS quinaprio * captopril * fosinopril * lisinopril * ALPHA BLOCKERS prazosin * doxazosin * terazosin * ANGIOTENSIN II 2-19-07 Last updated by djr ANTAGONISTS losartan valsartan ACCUPRIL CAPOTEN MONOPRIL ZESTRIL MINIPRESS CARDURA HYTRIN COZAAR ST ; DIOVAN ST and
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In addition, the following were reported for quinapril at an incidence 5%: depression, back pain, constipation, syncope, and amblyopia and
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Pizotifen 500microgram tablets Pizotifen Tab BP 1.5mg Potassium Effervescent Tab BPC 1968 Pravastatin Sodium Tab 10mg Pravastatin Sodium Tab 20mg Pravastatin Sodium Tab 40mg Prednisolone Tabs BP 1mg Prednisolone Tabs BP 5mg Prochlorperazine Tabs BP 5mg Prochlorperazine Tabs BP 5mg Procyclidine Tab BP 5mg Promazine Tab BP 50mg Propranolol Tab BP 10mg Propranolol Tab BP 40mg Propranolol Tab BP 80mg Propranolol Tab BP 160mg Quinap4il Tab 5mg Quinqpril Tab 10mg Qhinapril Tab 20mg Quinapdil Tab 40mg Quinine Bisulphate Tab BP 300mg Quinine Bisulphate Tab BP 300mg Quinine Sulphate Tab BP 200mg Quinine Sulphate Tab BP 300mg Ramipril Cap 1.25mg Ramipril Cap 2.5mg Ramipril Cap 5mg Ramipril Cap 10mg Ramipril 1.25mg tablets Ramipril 2.5mg tablets Ramipril 5mg tablets Ramipril 10mg tablets Ranitidine 150mg tablets Ranitidine 300mg tablets Ranitidine 150mg effervescent tablets Ranitidine 300mg effervescent tablets Salbutamol Tab BP 2mg Salbutamol Tab BP 4mg Selegiline Hydrochloride Tab 5mg Selegiline Hydrochloride Tab 5mg Selegiline Hydrochloride Tab 10mg Selegiline Hydrochloride Tab 10mg Senna Tab BP 7.5mg Simvastatin Tab 10mg Simvastatin Tab 20mg Simvastatin Tab 40mg Simvastatin Tab 80mg Sodium Bicarbonate Cap 500mg Sodium Cromoglicate Aqueous Eye Drops 2% w v Sodium Valproate Enteric-coated Tab BP 200mg Sodium Valproate Enteric-coated Tab BP 500mg Sodium Valproate Oral Soln 200mg 5ml S F Sotalol Tab BP 160mg Spironolactone Tab BP 25mg Spironolactone Tab BP 50mg Spironolactone Tab BP 100mg and
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Aims: To evaluate the long-term clinical and economic outcomes associated with therapy conversion to insulin detemir Levemir, Novo Nordisk ; from human insulin NPH ; in type 2 diabetes patients in the German setting. Material and Methods: A validated computer simulation model of type 2 diabetes was used to make long-term projections of clinical and cost outcomes based on patient characteristics and treatment effects from the German cohort of the PREDICTIVE observational study. The trial indicated that therapy conversion from NPH to insulin detemir was associated with a significant improvement in glycemic control HbA1c -0.6 % ; as well as reduced weight gain -0.382 kg m2 ; . Based on these clinical findings the model was used to evaluate life-expectancy, quality-adjusted life expectancy and direct medical costs for the detemir and NPH treatment arms. Future costs and clinical benefits were discounted at 5% per annum. Results: Treatment with insulin detemir was projected to improve life expectancy by approximately 0.13 years compared to NPH 7.14 0.12 versus 7.01 0.13 years ; . Qualityadjusted life expectancy was 0.28 quality-adjusted life years QALYs ; higher in the detemir arm than in the NPH arm 4.54 0.08 versus 4.26 0.08 QALYs ; . Direct medical costs over patient lifetimes were comparable in the detemir C 59, 585 1, ; and NPH C 59, 216 1, ; arms difference 369 ; . This led an incremental C cost-effectiveness ratio of approximately 1, 314 per QALY gained for C insulin detemir versus NPH, which represents very good value for money by commonly reported standards in Germany. Acceptability curve analysis indicated that there was a 99 % likelihood that insulin detemir would be considered good value for money at a willingness to pay threshold of 30, 000 per QALY gained. Conclusion: This health C economic evaluation, based on the findings of PREDICTIVE, indicates that treatment with insulin detemir is likely to be highly cost-effective versus NPH in type 2 diabetes patients in Germany.
Evidence of basal pituitary adrenal overactivity in first episode, drug na| ve patients with schizophrenia. na|ve Psychoneuroendocrinology, 29, 1065 1070. Psychoneuroendocrinology 29 and albendazole.
Last update price : sun july 22 2007 acid reflux allergy anti depressant anti histamine antibiotics anxiety arthritis asthma birth control blood clots blood pressure cardiovascular cholesterol diabetes enzymes epilepsy gastroenterology immunity defence influenza men's health menopause migraine muscle relaxers pain relief parkinson's penicillin schizophrenia sleep & insomnia stop smoking ulcers vitamins weight loss accupril the most important consumer information: brand name: accupril pronounced: ak-you-prill generic name: quinapril hydrochloride why is prescribed.
Robin Ertl, Ph.D. Louisiana State University, Baton Rouge, La., 1997 Dr. Harrison ; Peter Fuerst, Ph.D. Iowa State University, Ames, Iowa, 2003 Dr. Burgess ; Masaaki Furuno, Ph.D. Grad. School of Science, Nagoya University, Nagoya, Japan, 1998 Dr. Bult ; Doug Gould, Ph.D. University of Alberta, Canada, 2001 Dr. John ; James Hampton, Ph.D. University of Missouri, Columbia, Mo., 2003 Dr. Eppig ; Kimberly Huebsch, Ph.D. SUNY Upstate Medical University, Syracuse, NY 2002 Dr. Cox ; Kiyoshi Kano, Ph.D. University of Tokyo, Tokyo, Japan, 2002 Dr. Nishina ; Andre Khalil, Ph.D. University of Laval, Quebec, Canada, 2004 Dr. Nadeau ; Amy Kiernan, Ph.D. Boston College, Chestnut Hill, Mass., 1997 Dr. Gridley ; Doyeun Kim, Ph.D. Korea Advanced Institute of Science & Technology, Korea, 2002 Dr. Ackerman.
Atatrk University, Medical Faculty, Department of Biochemistry, Atatrk University, Biotechnology Application and Research Center, !Atatrk University, Medical Faculty, Department of Pharmacology, TR-25240, Erzurum, Turkey.
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