Koopmans Dijkers FW 1997 ; Repeat prescriptions: a study in general practice in the Netherlands. PROMOTORES: prof dr B Meyboom-de Jong, prof dr FM HaaijerRuskamp, prof dr AF Casparie Trigt van 1995 ; Making news about medicines. PROMOTORES: prof dr TFJ Tromp, prof dr FM Haaijer-Ruskamp Boerkamp E 1995 ; Assessing professional services quality: an application in health care. PROMOTORES: prof dr JC Reuijl, prof dr FM Haaijer-Ruskamp Denig P 1994 ; Drug choice in medical practice: rationals, routines, and remedies. PROMOTORES: prof dr FM Haaijer-Ruskamp, prof dr H Wesseling Jong-van den Berg LTW de 1992 ; Drug utilization studies in pregnancy: what can they contribute to safety assessment? PROMOTORES : prof dr MNG Dukes, prof dr H Wesseling. REFERENT: dr FM Haaijer-Ruskamp Zijlstra IF 1991 ; De regionaal klinisch farmacoloog. PROMOTORES: prof dr H Wesseling, prof dr FWJ Gribnau, prof dr C van Weel. REFERENTEN: dr FM Haaijer-Ruskamp, dr H Wollersheim Rehabilitation Programs Research from 1998 onwards.
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Blood Pressure Reduction All patients post stroke should be on an Ace inhibitor and thiazide e.g. Pe5indopril and Indapamide as per the PROGRESS trial, including those with "normotension" If patient remains hypertensive, aim for target BP of 140 85 130 in diabetics ; with additional agents Persistently elevated BP should not be lowered for 1 week following stroke, unless "malignant" Unless hypotensive systolic blood pressure less than 110mm Hg ; , patients should continue prior antihypertensive medication. Leave on pre-existing ACE inhibitors but ensure effective dose e.g. Perindopgil 4mg or Ramipril 10mg. Leave on prior thiazide medication unless hypokalaemic. If hypokalaemic, correct abnormality and consider Indapamide. If a patient is ACE inhibitor naive, start on once daily preparation such as Pfrindopril 2mg increasing to 4mg ; . Check U&Es and creatinine prior to and after starting or increasing the dose of ACE inhibitor. Once established on an ACE inhibitor consider adding a thiazide such as Indapamide 2.5mg immediate release as per PROGRESS study ; , and recheck U&Es after 2 weeks to exclude hypokalaemia or hyponatraemia. Note in the PROGRESS study, even patients with normal blood pressures systolic blood pressures 110 140 ; had their blood pressure reduced with Perindopr9l Indapamide with marked reduction in subsequent events. Consider blood pressure reduction in normotensives post stroke.
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ATLANTIC LAB MODERN MANUF PHARMINAR PHARMASANT LABS CONDRUGS INTERNAT GENERAL DRUG HOUSE MEDIFIVE PHARM CO MODERN MANUF PHARMASANT LABS PHARMINAR POLIPHARM T.M.N.IMPEX CONDRUGS INTERNAT MEDIFIVE PHARM CO MODERN MANUF PHARMASANT LABS CONDRUGS INTERNAT GPO MODERN MANUF PHARMASANT LABS ATLANTIC LAB CONDRUGS INTERNAT GPO INTERDRUG MEDIFIVE PHARM CO PHARMASANT LABS ATLANTIC LAB RHODIA MAYNE DBL B AUN LEO PHARM PRODUCTS TROIKAA PHARM B AUN FRESENIUS B AUN FRESENIUS PIERRE FABRE HAFSLUND NYCOMED HAFSLUND NYCOMED ELI LILLY & CO ELI LILLY & CO 80, for example, coversyl perindopril arginine.
To help your doctor understand how your arthritis is affecting your abilities, please fill out the questions on the next pages. Please try to answer each question, even if you do not think it is related to you at this time. There are no right or wrong answers. Please answer exactly as you think or feel. If this is the first time you are completing this questionnaire, please read the consent below and provide the information on the Instruction page before going on. Otherwise, just go on to page 1 now. To have your questionnaire scored by a computer and your information reported back to your doctor, we need your consent, your name and address, and some identifying information. You only need to provide this information once. In follow-up questionnaires, your initials and date of birth will be all that is needed to identify you to the databank. If you give your consent, your information will be stored in a computer database and reported back to your doctor for the purposes of your medical care. All of the information you provide is absolutely confidential. Except for your doctor and the National Databank for Rheumatic Diseases staff, no one will ever be able to identify you or your information. You will also receive an invitation to participate in a national arthritis research study that involves completing questionnaires every 6 months. Whether you choose to participate or not, your medical care will not be affected in any way. I agree to have my questionnaires scored and reported back to my doctor. I understand that my medical care will not be affected if I choose not to answer this or any future questionnaires, and all information will remain confidential. If I answer no, this questionnaire will remain in my rheumatology medical record. USE AND DISCLOSURE OF YOUR MEDICAL INFORMATION: By signing this form, you are authorizing the use and disclosure of your health information collected in connection with your participation in this research study. Your information will only be used in accordance with the provisions of this consent form and applicable law. If you decide to terminate your participation in the study, you may revoke your authorization, except to the extent that the law allows us to continue using your information. What Information Will Be Used or Disclosed? Your health information related to this study that you provided to us, including, but not limited to your medical history, symptoms, treatments, side effects, hospitalizations, infections, and work history. In addition, information from hospital or physician records used to clarify the information you provided. Who May Use and Disclose the Information? The following parties are authorized to use and disclose your health information in connection with this research study: 1 ; The Director of the National Data Bank for Rheumatic Diseases NDB ; , Frederick Wolfe, MD, and the research and data collection staff of the NDB, 2 ; A legally constituted review board charged to protect the safety human subjects in medical research, called the Via Christi Institutional Review Board IRB ; . Who May Receive Use the Information? * The parties listed in the preceding paragraph may disclose your health information to the following persons and organizations for their use in connection with this research study: 1 ; Qualified medical researchers at other universities, 2 ; The US Food and Drug Administration FDA ; , 3 ; Sponsors of the research study, 4 ; Your rheumatologist or physicians, 5 ; A legally constituted review board charged to protect the safety human subjects in medical research, called the Via Christi Institutional Review Board IRB ; . * Your information may be redisclosed if the recipients described above are not required by law to protect the privacy of the information. Your Access to Research Information: You will not be allowed to see or copy information in the NDB research records. Can I be identified personally? No, with 3 exceptions. 1 ; We may share identifying information with your rheumatologist or physicians if, for example, we contact your physicians to clarify information you have provided; 2 ; If requested by the human subjects safety board IRB 3 ; if ordered by a court. Otherwise, information that will allow you to be identified personally e.g., name, address, social security number, etc ; will be removed from all information used by 1 ; medical researchers at other universities, 2 ; FDA, 3 ; and study sponsors. Expiration: Your authorization for the use and or disclosure of your health information will continue indefinitely. However, you may withdraw from the research study at any time.
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Before claims for services not pre-certified as the Plan requires are considered for reimbursement, the Plan's utilization review consultant, Intracorp or ValueOptions, determines the appropriateness and medical necessity for the services retroactively. If the services would have been pre-certified had they been submitted as required, the claim is processed as usual, but a $200 administrative fee is applied to cover the additional cost of the post-service review. do not qualify for certification as appropriate and medically necessary, no benefits are payable.
Seven guidelines have been produced by the Fife Palliative Care Guideline Development Group and have all been approved by the Area Drug and Therapeutics Committee. Four guidelines were updated from previously issued guidelines, being: Control of Pain in Patients with Cancer Control of Constipation in Patients with Cancer Nausea Vomiting in Palliative Care Palliation of Breathlessness New guidelines introduced are: Anorexia in Palliative Care Pain Assessment in Patients with Cancer Oral Care Guidelines for Patients with Cancer and Palliative Care These guidelines will be added to the Fife Area Drug and Therapeutics Website or can be requested from the Department of Public Health on Tel. No.: 01592 226915 and risedronate, because perindopril court.
If patients cut back on their medication because of the cost, how likely are they to admit it? A recent study found that two thirds of patients did not tell their doctor-- and of those, 58% said that they did.
Inter-rater reliability IRR ; , the performance evaluation of the abstraction tool. Parametric measures of variation transferring data from its current form in MS Access to a statistical analysis package such as SAS or SPSS and running standard programs Positive predictive value the proportion of cases identified that were actually performed Potential decision modifying factors' PDMFs ; term to represent all factors assessed as a potential reason for excluding the case from measurement This term was used in place of `contraindications' in order to avoid a persistent source of confusion. Relative contraindications can become indications as science progresses e.g. beta-blocker use in heart failure ; . PDMFs are meant to include patient specific characteristics that would be expected to potentially modify the decision to prescribe a medication. PDMFs were divided into four categories according to the logic described below: 1 ; Absolute contraindications; 2 ; Noncontroversial potential decision modifying factors; 3 ; Factors considered to be controversial but having compelling evidence of benefit; and 4 ; Evidence less than compelling for an adverse effect. Setting where care was delivered physicians' office. ; Study population consisted of Medicare beneficiaries age 65 or older, enrolled in a Medicare + Choice plan or covered by Medicare Part B, and with any of the following three conditions: coronary artery disease, heart failure, or atrial fibrillation Temporality operationally defined the presence of the condition as existing throughout the measurement year if the case was identified at any time during the measurement year and subsequently confirmed during chart abstraction ; . This study operationally defined receipt of the service if evidence of that service existed at any time during the measurement year. Unit of analysis for the study was the managed care organization or the large group practice. Yield was defined as the proportion of cases retained with the more restrictive i.e. 2 or more, 3 or more ; criteria of the cases identified by 1 or more codes and salmeterol.
Manufacturer East India Chemical Works Pvt Ltd Calmed Drugs East India Chemical Works Pvt Ltd Calmed Drugs G. K. Traders East India Chemical Works Pvt Ltd East India Chemical Works Pvt Ltd Calmed Drugs C. I. Laboratories Jajodia Udyog [Product of Zydus Cadila] Stadmed Private Limited Dey's Drugs & Chemicals [Product of Elite Pharma] Centurion Laboratories Not quoted accepted Kansas Laboratories Pvt Ltd Stadmed Private Limited A. N. Pharmacia Laboratories [P] Ltd Shine Pharmaceuticals Ltd USV Limited Centurion Laboratories Not quoted accepted USV Limited Not quoted accepted Circular Pharma Not quoted accepted.
Andrew glenn president of pepsi was asked how a can of pepsi and a bag of crisps promoted together total cals 333 with 1 3 gms fat and 3 gms sugar ; could equate to five portions of fruit and vegetables; he replied that the committee should not ' get sidelined on sugar' and fluticasone.
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Lantelme, Pierre, Catherine Cerutti, Ming Lo, Christian Z. Paultre, and Michel Ducher. Mechanisms of spontaneous baroreflex impairment in Lyon hypertensive rats. Am. J. Physiol. 275 Regulatory Integrative Comp. Physiol. 44 ; : R920R925, 1998.--This experiment aimed at 1 ; comparing the spontaneous baroreflex sensitivity SBRS ; in Lyon genetically hypertensive LH ; , normotensive LN ; , and low blood pressure LL ; rats and 2 ; assessing some aspects of the mechanisms of its impairment in LH rats. Baroreflex was studied in control animals after an early chronic converting enzyme inhibition with perindopril and after a 4-wk infusion of ANG II in perindopril-treated rats. The SBRS was determined with a previously validated method, using statistical dependence between blood pressure BP ; and heart rate values recorded in freely moving animals. LH rats exhibited high BP, cardiac hypertrophy, and decreased SBRS LH, 1.3 0.2; LN, 2.5 0.4; LL, 2.2 0.4 beats min 1 mmHg 1 ; . Pe4indopril prevented the development of hypertension and cardiac hypertrophy and normalized SBRS. BP rose in LH and LL rats after ANG II infusion, but only LH rats, which developed a cardiac hypertrophy, had an impaired SBRS LH, 1.1 0.2; LN, 2.5 0.2; LL, 2.8 0.3 beats min 1 mmHg 1 ; . This impairment was partially reversed by an acute ANG II blockade with losartan. These results demonstrate that high BP does not account for the decreased SBRS in LH rats. SBRS impairment could result either from cardiac hypertrophy or from the direct effect of ANG II on the baroreflex loop. renin-angiotensin system; cardiac hypertrophy; statistical dependence and advil.
Oxygen delivery 1, 13, 14 ; . Moreover, a tight coupling between energy production and energy utilization within the fibers is commonly associated with high endurance capacity 41, 48, 49 ; . Mitochondrial energy production is the only source for long-term endurance exercise. Measurement of oxygen consumption of permeabilized muscle fibers can directly assess oxidative capacity of a given muscle. In these conditions, mitochondria are kept in their cellular environment and the respiring capacity of the whole mitochondrial population can be measured. Moreover, within the cellular architecture, mitochondria retain native regulatory properties that are lost after isolation 35 ; . Assessment of the mitochondrial function of predominantly glycolytic superficial gastrocnemius ; or highly oxidative soleus ; muscles showed that the later exhibited higher oxidative capacity, had lower ADP sensitivity, and was more dependent on mitochondrial creatine kinase than the glycolytic muscle, as previously described 17, 43, 48 ; . However, perindopril treatment had no effects on oxidative capacity and mitochondrial regulation by ADP and creatine. This was confirmed by measuring the activity of one Krebs cycle enzyme citrate synthase ; and of one complex of the respiratory chain cytochrome-c oxidase ; . None of these enzymes were affected by long-term perindopril treatment. Thus ACE inhibition did not alter oxidative capacity, in line with the maintained endurance capacity of the animals. Similarly, in trained human subjects with or without mild hypertension, ACE inhibition does not affect endurance exercise hemodynamics and VO2 max or parameters of energy metabolism 26, 28 ; . Another important determinant of endurance performance, strongly involved in the resistance to fatigue and adaptation to endurance exercise, is substrate utilization. Substrate utilization differs according to muscle phenotype. The soleus, an oxidative muscle, is able to actively oxidize fatty acids, whereas the gastrocnemius, a predominantly glycolytic muscle, produces energy mainly from glucose use. In addition to substrate specific import and transport systems in the cytosol, substrate specificity can also be observed at the level of mitochondria. It has been shown that preferential substrate utilization by mitochondria varies according to the fiber type 15 ; . Mitochondria isolated from fast fibers preferentially uses glycerol 3-phosphate, whereas slow type I fibers mainly use fatty acids as substrates. We thus designed muscle specific protocols to assess substrate utilization in permeabilized muscle fibers. Substrates were added sequentially in a tissue specific manner. The results show that octanoylcarnitine, a medium-chain fatty acid, was able to induce 70% of maximal respiration in soleus muscle, whereas these mitochondria could not use glycerol 3-phosphate. On the opposite, glycerol 3-phosphate could induce more than 60% maximal respiration in superficial gastrocnemius muscle composed of mainly type IIb fibers, whereas no oxidation of fatty acid could be observed. This muscle type-specific preferential substrate utilization by mitochondria was slightly but significantly higher in the perindopril-treated group. A 14% P 0.01 ; higher mitochondrial respiration with octanoylcarnitine was observed in soleus of perindopril-treated rats, whereas a 17% P 0.05 ; higher mitochondrial respiration was observed with glycerol 3-phosphate in gastrocnemius muscles compared with controls Fig. 1 ; . So, p3rindopril treatment resulted in an improved tissue specificity of substrate utilization. This could be due to in jap.
Workup author information introduction clinical differentials workup treatment medication follow-up miscellaneous pictures bibliography lab studies: if the cause of the pulmonary hypoplasia is renal pathology, serum creatinine, blood urea, and electrolytes levels should be measured to assess renal function and theophylline.
It shall be unlawful for any person who has knowingly received any income derived directly or indirectly from trafficking in a controlled substance to use or invest any part of that income, or any proceeds thereof, to acquire any property, or to establish or operate any commercial enterprise. a ; As used in this section, "property" includes real and personal property, whether tangible or intangible. b ; As used in this section, "commercial enterprise" means any proprietorship, partnership, corporation, association or other legal entity, including any individual or group not a legal entity, which is engaged in any business or commercial activity or whose activities affect business or commerce. 2 ; Any person who violates this section shall be guilty of a Class D felony and, in addition to other penalties prescribed by law, shall forfeit any property constituting or derived from any income received directly or indirectly from trafficking in a controlled substance. KRS 218A.141 marijuana Additional penalties for trafficking in controlled substance or, for example, perinxopril 8 mg.
9.1.1. The reimbursement rate shall be based on a per-transaction fee for the first 350, 000 transactions per year currently $0.21 ; and another per-transaction fee for all transactions over 350, 000 transactions per year currently $0.19 ; . A per-transaction fee is defined as any approved or reversed claim processed by Contractor for pharmacy services provided to eligible HCHP clients by an approved participating pharmacy for drugs ordered by a HCHP participating provider. 9.2. 9.2.1. Pharmacy Dispensing Services The County's pharmacy dispensing services reimbursement rates are based on the following rates: A specific discount from the applicable AWP for non-MAC generic drugs currently 55% ; for Contractor's network of retail pharmacy prescriptions and for mail order prescriptions. Discounts for Contractor's network of retail pharmacy prescriptions and for mail order prescriptions may be different. Reimbursement for the aforesaid services will be consistent with the amounts listed by Contractor in the proposal section of this RFP. A specific discount from the applicable AWP for non-MAC brand drugs currently 17% ; for Contractor's network of retail pharmacy prescriptions and for mail order prescriptions. Discounts for Contractor's network of retail pharmacy prescriptions and for mail order prescriptions may be different. Reimbursement for the aforesaid services will be consistent with the amounts listed by Contractor in the proposal section of this RFP and albenza.
Source: Emergency amended at 27 Ill. Reg. 10813, effective July 1, 2003, for a maximum of 150 days ; Section 140.492 Payment for Medical Transportation!
This page is strictly informational and not advise - if you and your MD's have other exit conditions that you are willing to share, please send them to cfs Folkarts May be freely copied site is placed in PUBLIC DOMAIN ; unless a appears on the page. Not medical advice - always consult with your MD on any treatments or supplement use. This website is intended to be a 'Rolodex' of summaries for CFS patients and and
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In the whole place was next to her. It was like something drew me there." They started talking and that was it. "He got me laughing so hard, I couldn't believe it, " says Millie. "I said, who is this guy?" Neither fit the other's search criteria. Millie counts off the differences: "He's Irish-American; I'm Puerto Rican. He lives in Springfield; I live in New York. He's seven years younger than me, too." But the two couldn't be happier. "Sure I'm lucky, " says Bryan, "but it's also because I worked at it. I really put myself out therefor years. We're living proof that true love exists, even with HIV. But it's not going to come knocking at your door." Louis Farmer & Derick Brown I love you; now take your meds Louis Farmer was at death's door in 1997, diagnosed with full-blown AIDS and bilateral pneumonia. He says his mother's prayers and, later, meds brought him back from the brink. In 2003, Louis met his dream man--the tall, dark Derick Brown--through a personal ad on Blackplanet . They were married last summer wearing these African robes ; in a ceremony attended by both their families and about 100 guests. They're very close and discuss everything-- including the status of Louis' health. So far so good, but Derick takes issue with Louis' decision to go off meds in 2003. "I just think it's better to stay with the treatment, " he says. Louis shoots back, "My blood tests are good--I feel healthy!" Louis says his husband's worrying is sometimes too much. "When I'm not feeling well, he says it's because I'm not on the meds. Then we have the discussion all over again." So how do they work it out? With a little chat after each of Louis' doctor's visits--and one key ground rule: "In the end, I make the final decisions, " says Louis. Derick con and
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Date: 01 12 05ISR Number: 4552091-5Report Type: Expedited 15-DaCompany Report #2005004121 Age: 49 YR Gender: Male I FU: I Outcome Dose Duration Hospitalization Initial or Prolonged Other 10 MG Chest Pain Demyelination Depression Drug Ineffective 0.5 MG Drug Toxicity Fatigue Feeling Abnormal Hypertension Hypoaesthesia Lethargy Mental Disorder Muscle Disorder Muscle Tightness Muscle Twitching Muscular Weakness Myalgia Nervousness Pain In Extremity Sleep Apnoea Syndrome Thyroid Function Test Perindopril Erbumine Perindopril Erbumine ; Hydrochlorothiazide Hydrochlorothiazide ; Topiramate Topiramate ; Naproxen Sodium Naproxen Sodium ; Acetylsalicylic Acid Acetylsalicylic Acid ; Bextra Valdecoxib ; Levothyroxine Sodium Levothyroxine Sodium ; SS PT Blood Creatine Phosphokinase Increased Blood Testosterone Decreased Report Source Consumer Product Neurontin Gabepentin ; Lipitor Atorvastatin ; Role Manufacturer Route.
Administration 17. 18. 19. Take the medication to the resident on cart or tray, per facility policy. If possible, give medications which are highest priority first. Knock on door, identify self and greet resident by name. Provide privacy, good lighting and elevate height of bed as appropriate. Identify resident following facility policy. Inform resident of medications to be given, explain any special instructions and encourage resident to participate as appropriate. Observe and listen carefully to the resident. Recheck anything that the resident says is new or wrong. Make preliminary pre-administration assessments as ordered and as indicated to determine contraindication and therapeutic effects. Assist resident to as upright a position as possible. For unit-dose medicines, check the label per facility policy Check #3 ; , then open the unit-dose package and place in medicine cup or residents hand. Check residents preference for taking multiple drugs separately or all together. Give ordered medication s ; to resident by cup, or gently place medicine in residents mouth if indicated. Follow the SIX RIGHTS and
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Can J Clin Pharmacol Vol 13 1 ; Winter 2006: e75-e80; Feb 1, 2006 Canadian Society for Clinical Pharmacology. All rights reserved.
Thousands of animals given up or lost appear in shelters every year in need of safety and proper care. However, in states that practice pound seizure, these animals may find themselves in a laboratory instead. Pound seizure is the sale or release of cats and dogs from a pound or shelter to a research, testing, or educational facility. The regulation regarding this practice varies from state to state. In three states--Minnesota, Oklahoma, and Utah--it is required that publicly funded shelters and pounds sell dogs and or cats to institutions for experimental or educational purposes. In states such as Ohio and Wisconsin a shelter does not even make surrendered companion animals available for adoption but must provide them directly to the institution upon request of the animals. Several states have no law either way regarding pound seizure, and often it is left to the discretion of local politicians. In 1966, the Laboratory Animal Welfare Act, now known as the Animal Welfare Act AWA ; was created to not only establish humane standards for the care and transport of animals used in laboratories but also to regulate dealers who sell animals to research institutions. In 1990, an amendment was added requiring shelters to hold animals for a minimum of five days before being sold to a research facility to allow the animals' guardians time to claim their companions. The AWA, enforced by the U.S. Department of Agriculture USDA ; , requires that animal dealers be classified as Class A or Class B dealers. Class A dealers are breeders, and Class B dealers may breed animals, but they also purchase and sell live or dead animals obtained from many sources, including pounds and shelters. Class B dealers are required to have proper documentation assuring legal acquisition and a minimum holding time of 10 days following an acquisition before animals can be sold to a research facility. Although violating these regulations could result in a fine, some will try to obtain animals illegally and falsify the necessary documents to a laboratory. By design, pound seizure diminishes the credibility of shelters, which are thought to be safe havens for animals in need. Further, animals typically sold to dealers are docile and healthy, which would also make them prime candidates for adoption if afforded the opportunity. Considering that animals coming from a shelter were probably raised in a home, the confines of a laboratory can be taxing on the animals' mental and physical states. Additionally, animals obtained from shelters have unknown genetic and medical histories which can have a significant impact on the outcome of a particular experiment. To learn more and find out if pound seizure is practiced in your state, please visit banpoundseizure . If pound seizure is being practiced in your state, contact your local representatives about your opposition to this inhumane practice.
Atenolol in comparison with other antihypertensive drugs. In an acute study, both ramipril and atenolol reduced blood pressure, and the diastolic pressure fall was similar in the brachial artery and aorta, but the systolic pressure fall for ramipril was significantly greater than for atenolol by 5.2 mmHg, p 0.0001 ; in the aorta compared with the brachial artery.45 Systolic blood pressure is not accurately recorded by measurement of arterial pressure at the brachial artery.46 The peak systolic blood pressure represents only one point on the systolic pulse wave and takes little notice of the duration of the systolic period or the shape of the systolic wave. In addition, the significant pressure related to cardiac function and work is the pressure at the origin of the aorta. The heart expels blood against this pressure. The diastolic pressure in the brachial artery is a close approximation to the central aortic diastolic pressure, which is 1 to mmHg higher. However, brachial artery systolic pressure is not a good estimate of the central aortic systolic pressure. In young healthy individuals, the central aortic systolic pressure is much lower than the brachial artery systolic pressure.47 This is the result of the reflected wave, which returns to the central aorta late in systole with little amplification of the aortic pressure. However, it has returned to the brachial artery during contraction, leading to amplification of the brachial artery systolic pressure, which is higher than the central aortic systolic pressure.48, 49 As blood vessels become stiff, the pulse wave is transmitted more rapidly and returns to the heart during contraction, resulting in a greater augmentation of the central aortic systolic pressure.50, 51 Other factors, such as slow heart rate, can also affect pulse wave velocity and augmentation of central aortic systolic pressure.52 Treatment with atenolol reduces brachial blood pressure, but does not lower central aortic systolic pressure as much as treatment with angiotensin-converting enzyme inhibitors perindopril, enalapril ; , calcium channel blockers felodipine, amlodipine ; and hydrochlorothiazide.53 Therapy based on typical blood pressure measurements may overestimate the effect of atenolol on central aortic systolic pressure and underestimate the effectiveness of other antihypertensive drugs. The Conduit Artery Function Evaluation CAFE ; study, a sub-study of ASCOT, has shown that despite similar brachial systolic blood pressures between the amlodipine-based regimen and the atenolol-based regimen, there were statistically significant reductions in central aortic pressures with the amlodipine-based regimen.54 In addition, while metoprolol blunted the rapid.
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Monotherapy: the recommended initial dose of perindopril, in patients not on diuretics, is 4 mg once daily and
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Above, from left to right: Orange Regional Board of Directors Chair Alanna Smith, Cardiac Cath Lab Director Martha Hall, Chairman, Orange Regional Foundation Board of Trustees and Orange Regional Board of Directors member Jerry Bergman, first Cath Lab patient Gabor Ferencz, Administrator of Cardiopulmonary & Diabetes Services Anne Nelson, and Cardiac Cath Lab Co-Medical Director Dr. Inderpal Singh.
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Altogether these results show that perindopril protects the strcs from irradiation-related toxicity and that the increase in mice survival is mediated by inhibition of the angiotensin ii pathway through the at1 receptor and that the same effects can be obtained with an at1 receptor antagonist.
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60. International Obesity Task Force. "Working Groups." : iotf. org groups . Accessed April 13, 2005. 61. Weight Watchers International, Inc. "Scientific Advisory Board." 2005. 62. Rigby NJ, Kumanyika S, James WP. "Confronting the epidemic: the need for global solutions." Journal of Public Health Policy. 2004; 25 3-4 ; : 418-23. 63. University of Pennsylvania School of Medicine. "Shiriki Kumanyika, Ph.D., M.P.H." : cceb.upenn main people kumanyika . Accessed May 1, 2005. 64. International Association for the Study of Obesity. "IOTF Update." IASO Newsletter. 2004; 6 1 ; . : iaso. org newsletter may2 . Accessed June 28, 2005. 65. Landers. American Medical News. 2003. 66. Kushner. Obesity Management. 2005. 67. "Tracking the trends in weight loss: Cut the calories." Transcript. January 1, 2004. 68. Centers for Obesity Research and Education. "Weight management program at the Northwestern Memorial Wellness Institute." 69. Center for Science in the Public Interest. "Integrity in Science Database." 70. Food and Drug Administration Center for Drug Evaluation and Research Endocrinologic and Metabolic Drugs Advisory Committee. "Open Session." September 28, 1995. : fda. gov ohrms dockets ac 95 3107t1a . Accessed March 28, 2005. 71. Fraser. 1998. p. 199. 72. Manson JE, Faich GA. "Pharmacotherapy for obesity--do the benefits outweigh.
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