Singulair will not be approved for allergic rhinitis. * PHARMACY PROTOCOL FOR PRIOR AUTHORIZATION ZETIA ezetimibe ; 1. Is the member currently taking a formulary approved HMG-CoA? Lipitor, Lescol, Pravachol ; If yes, proceed to question 2, if no, it will be denied. With an HMG-CoA reductase inhibitor, as adjunctive therapy to diet for the reduction of elevated total cholesterol, LDL-C, and Apo B in patients with primary hypercholesterolemia. In combination with either Lipitor atorvastatin ; or Zocor simvastatin ; , for the reduction of elevated total cholesterol and LDL-C levels in members with homozygous familial hypercholesterolemia HoFH ; . 2. Is the member receiving the maximum tolerated dose of the HMG-CoA? examples include: Lescol 40mg increased to 80mg, Lipitor 20mg increased to 40mg, Pravachol 20mg increased to 40mg, Zocor 20mg increased to 40mg ; . If yes, the Zetia in combination with the HMG-CoA therapy will be approved. If no, the HMG-CoA dose must be increased as tolerated and then be re-evaluated in 6 months. Zetia will not be approved for monotherapy except for familial sitosterolemia. 3. Does the member have homozygous familial sitosterolemia? If yes, Zetia will be approved for monotherapy. Zetia is approved as adjunctive therapy to diet for the reduction of elevated sitosterol and campesterol levels in members with homozygous familial sitosterolemia.
Results: 1. Basic conditions befor treatment started: There were no significant differences between the groups for age, body height, body weight, blood and urine routine parameters, liver and kidney function, blood glucose and blood lipid levels. All groups were comparable at the beginning. 2. Changes of lipids see table 1 ; : TC, LDLc and TC-HDLc ; HDLc-ratio significantly decreased in each group after the treatment. Combination of Lovastatin + Omega-3 as well as Zhibituo decreased the TG levels and increased the HDLclevels significantly. Simvashatin was able to decrease TG levels significantly but only slightly increased HDLc levels. The extent of the TC decrease in all groups was assessed: the extent for this decrease using the combination of Lovastatin + Omega-3 was significantly stronger than that in the Lovastatin or Simvasatin group. The extent of the decrease in the Zhibituo group was significantly stronger than that in the Lovastatin group but not different from that of the Simvasyatin group. This indicated that the TG decrease was based on the Omega-3 component. The increase of HDLc was significant in two groups but the comparison among all groups showed no significant difference. 3. Comparison of the therapeutic effect on TC decrease and the TC-HDLc HDLc ; ratio: The rates of significant effectivness and effectivness were similar. The total effectivness was the highest in the Simvatatin group and the lowest in the Lovastatin group but the differences were not significant Ridit value: 0, 46; p 0.05 ; . The percentage rate of reaching the therapeutic goal to decrease TC were 5060.87% in all groups and the statistical comparison showed no statistical difference. 4. The comparison of TG decrease: the rate of reaching this target was 60% in the combined Lovastatin + Omega-3 group and a little bit more than 40% in all other groups. 5. Rate of reaching the therapeutic target of TC-, TG- and LDLc-decrease: the Zhibituo group was the best 42.11% ; while the Lovastatin group was the.
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To provide up to date information and advice on drugs and mental illness. people who use drugs and have experienced mental illness and the staff who work with them. Some swearing and graphic images of drug use. 39-41 Thomas Street | Manchester M4 1NA | lifeline is a registered charity no: 515691 + 44 0 ; 161 839 2075 | lifelinepublications | publications lifeline Digital copies of these booklets can also be viewed at : eastmidlands.csip dd index.
Photodynamic therapy PDT ; has received increasing attention as a new treatment modality of tumours and other nonmalignant disorders. PDT is based on the interaction of a lightactivated drug photosensitizer ; followed by visible light illumination of the pathological area. Upon photoactivation of the sensitizer, reactive oxygen species are produced, leading to irreversible destruction of the treated tissues. General considerations on both physical and biological processes will be introduced. In 1978, Dougherty reported the first clinical utilization of hematoporphyrin derivatives HpD ; in the PDT of human cancers. The purified version of HpD, Photofrin, was first approved for PDT of bladder cancer in Canada in 1993. Since then, it has been approved all around the world for the treatment of lung, esophageal, bladde or gastric cancers. However, Photofrin has an heterogeneous chemical composition, a poor tumoral selectivity and induces a long-term skin sensitivity. The design of new photosensitizers having well-defined stucture, great selectivity for tumour cells, high photobiological efficiency, fast elimination from healthy tissues and strong light absorption in the red region of the visible spectrum is thus an important challenge for the chemist community. A number of second generation photosensitizers have been developed and evaluated for their potential in PDT porphyrins, chlorins, phthalocyanines, benzoporphyrin derivatives. ; .In this context, the search for optimized delivery systems also knows an important development. Aminolevulinic acid ALA ; , as a prodrug for endogenous porphyrin has also been extensively examined for PDT. In Europe, several important milestones include the recent regulatory approval given in 2000 for Visudyne BPD-MA ; for the treatment of age-related degeneration AMD ; and for Foscan mTHPC, 2002 ; as an agent for palliative treatment of head and neck cancer. However, continued research is still necessary to develop new sensitizers with a high photoactivity and increased therapeutic index. Third generation photosensitizers are now being designed whereby the absorbing chromophore is linked to a targeting system to increase the potential in PDT. A survey of the strategies developed in the field of new sensitizers along with the most relevant clinical results will be given, because picture simvastatin.
Minnesota Department of Health December 12, 2001 health ate.mn.
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The following more common side effects of zocor are usually mild and may go away: headache constipation diarrhea gas upset stomach and stomach pain rash muscle and joint pain call your doctor if any of the following, more serious, side effects occur: muscle weakness, tenderness, or pain nausea, vomiting, and stomach pain brown or dark urine tiredness yellowness of the skin and whites of the eyes neuropathy numbness and tingling ; affecting the hands, arms, feet, and legs for more information and label information zocor’ s approved patient and label information health's cholesterol center understanding cholesterol-lowering medications drugs fda zocor - company site synonyms and keywords cholesterol, cholesterol level, high cholesterol, high cholesterol level, bad cholesterol, good cholesterol, hdl, ldl, hdl-c, ldl-c, high-density lipoprotein, low-density lipoprotein, cholesterol-lowering medication, cholesterol management, cholesterol test, lipid, coronary heart disease, coronary event, statin, statins, simvastatin, zocor authors and editors author: mary l windle, pharm d, adjunct assistant professor, university of nebraska medical center college of pharmacy; pharmacy editor inc editors: william l isley, md, senior associate consultant, associate professor of medicine, division of endocrinology, diabetes, and metabolism, mayo clinic of rochester; francisco talavera, pharmd, phd, senior pharmacy editor, ; michael e zevitz, md, clinical assistant professor, department of medicine, rosalind franklin university of medicine and science, chicago and
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This one-day course will review fundamental principles of adaptive immunity and immunological tolerance, with an emphasis on recent advances. Topics to be discussed include: antigen processing and presentation including dendritic cell biology T lymphocyte activation and homeostasis including costimulation and apoptosis innate immunity including Toll receptors and the biology of NK cells cytokines and helper T Cell subsets; and self-tolerance and its breakdown. Ample time will be scheduled for discussions and interactive exchanges with the faculty. Outlines of lectures and illustrations will be provided in a course syllabus and on CD-ROM for each student. Faculty Abul K. Abbas, MD University of California - San Francisco San Francisco, CA Hidde L. Ploegh, PhD Harvard Medical School Boston, MA Schedule Lecture 1: Innate Immunity Lecture 2: Antigen Presentation Lecture 3: Activation and Regulation of T Lymphocytes Lecture 4: Effector Mechanisms of Cell-Mediated Immunity Lecture 5: Lymphocyte Development Lecture 6: Tolerance and Autoimmunity.
3. Scandinavian Simvxstatin Survival Study Group. Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: The Scandinavian Simvastatin Survival Study 4S ; . Lancet. 1994; 344: 13831389. Shepherd J, Cobbe SM, Ford I, et al. Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia. West of Scotland Coronary Prevention Study Group. N Engl J Med. 1995; 333: 13011307. Sacks FM, Pfeffer MA, Moye LA, et al. The effect of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levels. Cholesterol and Recurrent Events Trial Investigators. N Engl J Med. 1996; 355: 10011009. Gotto Jr, Boccuzzi SJ, Cook JR, et al. Effect of lovastatin on cardiovascular resource utilization and costs in the Air Force Texas Coronary Atherosclerosis Prevention Study AFCAPS TexCAPS ; . AFCAPS TexCAPS Research Group. J Cardiol. 2000; 86: 11761181. Heart Protection Study Collaborative Group. MRC BHF Heart Protection Study of cholesterol lowering with simvastatin in 20, 536 high-risk individuals: A randomised placebo-controlled trial. Lancet. 2002; 360: 722. Heart Protection Study Collaborative Group. MRC BHF Heart Protection Study of antioxidant vitamin supplementation in 20, 536 high-risk individuals: A randomised placebo-controlled trial. Lancet. 2002; 360: 2333. Hodges RE. Vitamin E and coronary heart disease. J Diet Assoc. 1973; 62: 638642. Gey KF. The antioxidant hypothesis of cardiovascular disease: Epidemiology and mechanisms. Biochem Soc Trans. 1990; 18: 10411045. Morris CD, Carson S. Routine vitamin supplementation to prevent cardiovascular disease: A summary of the evidence for the U.S. Preventive Services Task Force. Ann Intern Med. 2003; 139: 5670. Marchioli R, Schweiger C, Tavazzi L, Valagussa F. Efficacy of n-3 polyunsaturated fatty acids after myocardial infarction: Results of GISSIPrevenzione trial. Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto Miocardico. Lipids. 2001; 36 Suppl ; : S119S126. 13. Yusuf S, Sleight P, Pogue J, et al. Effects of an angiotensin-converting enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients. The Heart Outcomes Prevention Evaluation Study Investigators. N Engl J Med. 2000; 342: 145153. Brown BG, Zhao XQ, Chait A, et al. Simvastatin and niacin, antioxidant vitamins, or the combination for the prevention of coronary disease. N Engl J Med. 2001; 345: 15831592. Kritchevsky SB, Kritchevsky D. Serum cholesterol and cancer risk: An epidemiologic perspective. Annu Rev Nutr. 1992; 12: 391416 and
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Here is short list: narayanan kutty, kodungallor madathiparambil ( 37) found badly beaten up at matha ashramam, vallikkavu, on 4th april 1990 and admitted to medical college hospital trivandrum.
It exerts its therapeutic action in a similar way to other statins such as simvastatin, atorvastatin, pravastatin and fluvastatin and
sumatriptan.
AGENERASE amprenavir ; Oral Solution MEVACOR lovastatin ; , ZOCOR simvastatin ; , and LIPITOR atorvastatin ; cholesterol-lowering medicines ; Phenobarbital used for seizures ; TEGRETOL, CARBATROL carbamazepine; used for seizures and trigeminal neuralgia ; DILANTIN phenytoin; used for seizures ; DECADRON dexamethasone, used to reduce inflammation ; Hormonal contraceptives e.g., birth control pills ; because the effectiveness of one or both drugs may be decreased. Talk to your doctor about choosing a different type of contraceptive. Vitamin E. AGENERASE contains high daily doses of vitamin E that could interfere with medicines that help you stop bleeding.
Pharmaceutical Research and Manufacturers of America v. Maine, No. 00-2446 1 Cir., May 16, 2001 and
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There have been no deaths associated with medical abortion and there are no known effects on future fertility from the procedure or the medications alone.
Medical Staff General Business Luncheon January 15 and February 19 Noon, Manor Auditorium OB&GYN Department January 25 8: 00 a.m., room 3504 Pediatrics Department February 15 7: 30 a.m., room 3504 and tagamet.
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| The scandinavian simvastatin survival study 4sAdditional prescriptions per month. [Those pharmaceuticals designated as routine exceptions to the monthly limit remain in effect.] Beneficiaries enrolled in these DDSN waiver programs are also exempt from copayment requirements on all Medicaid-covered prescriptions dispensed to them. Individuals interested in possible HASCI enrollment may contact 866-867-3864 toll-free ; for additional information. The Family Planning Waiver FPW ; is a statewide research demonstration project that provides Medicaid family planning services coverage for women at or below 185% of the federal poverty level FPL ; . The CMS has renewed the family planning waiver demonstration project through December 31, 2007, with the addition of a primary care partnership objective to promote medical homes for waiver participants. The DHHS will partner with community health centers to accomplish this objective. This increase in access to primary medical care homes will expand access to preventive services as well as services related to family planning. However, only family planning services are Medicaid reimbursable. Outpatient contraceptive pharmaceuticals and devices both legend and OTC ; , examinations, laboratory services, abstinence counseling and education, office visits, and other services related to family planning are covered under this waiver. Treatment for routine side effects or complications associated with the various family planning methods other than changing the birth control method ; is not covered. Treatment costs, in these instances, are the responsibility of the patient. Pregnancy-related and fertility services are also noncovered under the FPW. If a FPW participant becomes pregnant during the time she is covered under this waiver, she must reapply with the local DHHS county eligibility office in order to be considered for full Medicaid benefits. Participants must present a prescription for any contraceptive pharmaceuticals or devices that are dispensed, including OTC items. Providers are reminded that all prescriptions written for family planning pharmaceuticals, devices, or supplies are exempt from the collection of the $3.00 Medicaid copayment; also, for adult participants, such items do not count toward and temovate.
Nitrofurantoin is indicated for the treatment of urinary tract infections 1, 2 ; . To date, the Australian Drug Reactions Advisory Committee ADRAC ; has received 576 reports of suspected adverse reactions to nitrofurantoin, with pulmonary reactions described in 142 reports 25% ; , including 46 reports received since the last ADRAC publication on the subject in 1995 3 ; . Forty of the reports of pulmonary reactions related to longterm use and were consistent with pulmonary fibrosis or interstitial pneumonitis. The most common presenting symptoms were dyspnoea or cough, but some had hypersensitivity features fever, rigours, pruritus, rash, or eosinophilia ; . The reports usually involved elderly females, probably reflecting usage. The nitrofurantoin doses were 50300 mg day recommended daily dose for prophylaxis 50100 mg ; . Some reports described severe pulmonary reactions with exposure as low as 50 mg day for 8 months. The longest time to onset was 16 years. Recovery by the time of reporting was documented in 12 cases, but some patients showed indications of persistent lung damage. Two patients died as a result of pulmonary toxicity, for example, statins simvastatin.
We are also working on the development of enhanced formulations of a number of disclosed compounds fenofibrate, simvastatin, paroxetine, venlafaxine, sumatriptan and acyclovir ; , as well as a number of undisclosed compounds and terbinafine.
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New Drug or Supplemental Applications Filed by Manufacturer Clofarabine ILEX ; Loteprednol etabonate tobramycin Oxycodone Pregabalin Pfizer ; Simvastatin Ezetimibe Schering-Plough Merck ; Tegaserod maleate Zelnorm Novartis ; Menostar Berlex ; Treatment of patients with chronic and persistent constipation and persistent symptoms of straining, hard or lumpy stools, and infrequent defecation Prevention of osteoporosis 11 03 Bausch & Lomb ; Remoxyl Pain Therapeutics ; Treatment of refractory or relapsed pediatric acute lymphoblastic leukemia Treatment of steroid-response inflammatory ocular conditions in patients who have or are at risk of developing superficial bacterial ocular infections Long-acting formulation of oxycodone that is designed to decrease drug abuse Treatment of epilepsy, neuropathic pain, and generalized anxiety disorder. Treatment of lipid abnormalities 10 03 11.
For oesophageal candidiasis, the recommended dose is 200 mg on the first day, followed by 100 mg to 200 mg once daily. Doses up to 400 mg day may be used, based on medical judgment of the patient' response to therapy. Patients with oesophageal candidiasis should s be treated for a minimum of three weeks and for at least two weeks following resolution of symptoms and
tetracycline.
Primary prevention CARDS * AFCAPS HPS ASCOT PROSPER HHS 4S Re-analysis CARE LIPID * LIPS HPS 4D VA-HIT DAIS FIELD ASPEN 2838 155 2912 Atorvastatin 10 Lovastatin 40 Simvastatin 40 Atorvastatin 10 Pravastatin 40 Gemfibrozil 1200 Simvastatin 2040 Pravastatin 40 Pravastatin 40 Fluvastatin 80 Simvastatin 40 Atorvastatin 20 Gemifbrozil 1200 Fenofibrate 200 Fenofibrate 200 Atorvastatin 10 -37 p 0.001 ; -44 p NS ; -33 p 0.0003 ; -16 p NS ; + 27 -68 p NS ; -55 p 0.002 ; -42 p 0.001 ; -25 p 0.05 ; -19 p NS ; -47 p 0.04 ; -18 p 0.002 ; -8 p NS ; -32 p0.004 ; -23 p NS.
Anusak Kijtawornrat. Comparison of measurements of glomerular filtration rate using single-injection of inulin and standard creatinine clearance in dogs with renal arteries stenosis. Bangkok : Chulalongkorn University, 2001. 15 p. R E19026 ; Chollada Buranakarl. Study of norepinephrine kinetics in dogs with 2K2C-renovascular hypertension. Bangkok : Chulalongkorn University, 1998. 41 p. R E19615 ; Chutima Udom. Changes in renal functions during acute L-arginine loading in dogs. Bangkok : Chulalongkorn University, 1995. 57 p. T E9781 ; Hutheesing, Otome. Elephant female and dog male : a Lisu metaphor in change. [S.l. : s.n.], [1986]. iv, 241 leaves. R E5929 ; Naruepon Kampa. Renal nuclear imaging : effect of selection of various parameters on glomerular filtration rate measured by 99m Tc - DTPA nuctear imaging in dogs. Uppsala : Swedish Universtiy of Agricultural Sciences, 2000. 51 p. T E22099 ; Pakorn Thaiyanant. Kinetics of IgG and IgM antibody responses to antirabies vaccines in man and survey of rabies in healthy dogs. Bangkok : Mahidol University, 1976. 2 119 ; . T MF09766 ; Supang Kondee. Development of HPLC method for analysis of plasma simvasttatin and s8mvastatin hydroxy acid and application to bioequivalence studies in dogs. Bangkok : Chulalongkorn University, 1998. 137 p. T E19624 ; Suppawiwat Ponglowhapan. Influence of glucose and fructose in the extender on long - term storage of chilled canine semen. Uppsala : Swedish University of Agricultural Sciences, 2003. 53 p. T E22090 ; Tawin Inpankaew. Zoonotic canine giardiasis in temple-related communities in Bangkok, Thailand. Bangkok : Mahidol University, 2005. 66 p. T E33127 ; Theerawat Swangchan-uthai. Effect of GnRH agonist implantation on reproductive performance of prepubertal female dogs. Bangkok : Chulalongkorn University, 2003. 55 p. T E24975 and
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17. MRC BHF Heart Protection Study of cholesterol lowering with sjmvastatin in 20 536 high-risk individuals: a randomised placebo-controlled trial. Lancet 2002; 360: 7-22 Edwards JE, Moore RA. Statins in hypercholesterolaemia: a dosespecific meta-analysis of lipid changes in randomised, double blind trials. BMC Fam Pract 2003; 4: 18 Sever PS, Dahlof B, Poulter NR, et al. Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations, in the Anglo-Scandinavian Cardiac Outcomes Trial Lipid Lowering Arm ASCOTLLA ; : a multicentre randomised controlled trial. Lancet 2003; 361: 1149-58 Wei L, Ebrahim S, Bartlett C, et al. Statin use in the secondary prevention of coronary heart disease in primary care: cohort study and comparison of inclusion and outcome with patients in randomised trials. BMJ 2005; 330: 821 McKenney JM, Jones PH, Adamczyk MA, et al. Comparison of the efficacy of rosuvastatin versus atorvastatin, simvastatin, and pravastatin in achieving lipid goals: results from the STELLAR trial. Curr Med Res Opin 2003; 19: 689-98 Taylor AJ, Kent SM, Flaherty PJ, et al. ARBITER: Arterial Biology for the Investigation of the Treatment Effects of Reducing Cholesterol: a randomized trial comparing the effects of atorvastatin and pravastatin on carotid intima medial thickness. Circulation 2002; 106: 2055-60 van Wissen S, Trip MD, Smilde TJ, et al. Differential hs-CRP reduction in patients with familial hypercholesterolemia treated with aggressive or conventional statin therapy. Atherosclerosis 2002; 165: 361-6 Wiklund O, Mattsson-Hulten L, Hurt-Camejo E, et al. Effects of simvastatin and atorvastatin on inflammation markers in plasma. J Intern Med 2002; 251: 338-47 Braunstein JB, Cheng A, Cohn G, et al. Lipid disorders: justification of methods and goals of treatment. Chest 2001; 120: 979-88 Shepherd J, Hunninghake DB, Barter P, et al. Guidelines for lowering lipids to reduce coronary artery disease risk: a comparison of rosuvastatin with atorvastatin, pravastatin, and simvastatin for achieving lipid-lowering goals. Atheroscler Suppl 2004; 5: 115-23.
Average daily dose: niacin 2400 mg 2000 mg; simvastatin 13.6 mg 6 mg and
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Texas House Bill #341 the "Andrea Yates Bill, " states all healthcare providers, individual and organizational, that treat pregnant or postpartum women, are required to give out resources for counseling regarding parenting and postpartum illnesses. These providers must document that this information has been received and keep the documentation for three years. As indicated in the article on page 14, treatments for postpartum illnesses can be very effective. If you are pregnant and have not yet received information about these illnesses, contact your healthcare provider. For postpartum depression brochures and information or women's mental health resources visit the Mental Health Association of Greater Houston, mhahouston.
FIGURE 1. Total BAL cellularity and differential cell count after treatment with simvastatin i.p. BALB c mice were sensitized with OVA and then challenged with OVA intranasally on 3 consecutive days days 2527 ; . Simvastatin 40 or 4 mg kg i.p. ; was given 30 min before each Ag challenge. Control mice were given PBS. BAL cell counts were performed on day 28. Treatment with simvastatin 40 mg kg ; resulted in a significant reduction in total cell count A ; , eosinophilia B ; , and macrophage number C ; compared with PBStreated controls. No significant difference was seen in BAL lymphocyte levels D ; . Normal mice challenged intranasally with OVA had lung cellularity similar to that of mice given PBS alone not shown ; . Data are expressed as the mean SEM n 14 ; . , 0.01 by ANOVA.
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As a result, company spokeswoman lesley fishman said, the drug maker didn't seek fda approval for treating that condition, for example, effect of simvastatin.
Usual therapies: all therapies in stages a, b, and c plus: evaluation for other treatment options, such as a heart transplant, ventricular-assist device, other surgeries, continuous iv infusion of inotropic drugs, and research therapies and sporanox.
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Health in to all hospital referral of male males.
4th year medical student, New York College of Osteopathic Medicine * Assistant Clinical Professor of Dermatology, Mount Sinai Medical Center, New York, NY, Chief of Dermatology, St. Barnabas Hospital and Bronx Veterans Affairs Medical Center * Clinical Instructor of Neurology, Mount Sinai Medical Center New York, NY * Dermatology Program Director, Lutheran Medical Center, Brooklyn, NY ABSTRACT Hyperhidrosis is the excessive production of sweat in amounts greater than needed physiologically for thermoregulation. A literature review was performed concerning the pathophysiology, diagnosis and treatment of hyperhidrosis.
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