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A feature of HEPP News providing concise solutions to correctional HIV-related problems. Adapted From: NIH's Management of HCV : niddk.nih.gov health digest pubs chrnhepc chrnhepc and suprax. The Prescription Drug Information Project PDIP ; is a collaborative venture between the University of California UC ; , with UC Davis as the lead site, and the California HealthCare Foundation. The goal of the PDIP is to support clinicians and patients in California in their day-to-day decisions about which drugs to prescribe or take. The governing principle is that accurate, understandable information on effectiveness, side effects, and costs will help clinicians and patients to select the best drug or treatment at the best price. The PDIP focuses on drugs that are currently promoted directly to the public. The United States has witnessed a steep increase in direct-to-consumer DTC ; advertising of prescription drugs, from $791 million in 1997 to nearly $2.5 billion in 2001.1 Fewer than 40 DTC drugs account for most of these expenditures. Many physicians, managed care organizations, and health policy analysts believe that DTC advertisements provide incomplete or inaccurate information to consumers, which nonetheless contribute to increased consumer demand for DTC drugs. Furthermore, there is widespread concern that consumer demand translates into inappropriate and unnecessary prescribing of DTC drugs. On the other hand, proponents of DTC advertising argue that advertisements raise awareness of undertreated conditions and encourage more dialog between patients and physicians. Still, proponents and critics agree that making accurate information accessible to both consumers and clinicians is never a bad thing. To this end, the PDIP has two components: information retrieval and dissemination. The information retrieval process is led by UC Davis, whereas the dissemination campaign is coordinated by the California HealthCare Foundation CHCF ; . In the first round of information retrieval, the project focuses on treatments for gastroesophageal reflux disease GERD ; , hypercholesterolemia, and osteoarthritis OA ; . In subsequent phase, treatments for depression, allergic rhinitis, and asthma will be undertaken.
Drugs are rated a, b, c, d, and x. Orange-red variety or "Himedaka" This strain with orange body color is commercially available and widely used for research and testing because it is the easiest to be maintained in laboratory conditions. This out-bred wild-type ; strain is well suited to testing EASs [24]. d-rR or S-rR Yamamoto ; strain The genotypic sex of this strain can be identified using a color marker and the strain is therefore well suited to EAS testing [11]. The sex-specific body color is due to the location of the recessive gene r ; for the orange-red color in xanthophores on the X chromosome and the wild-type allele R ; on the Y chromosome crossing-over rate between X and Y chromosomes is ca. 0.3 % ; . Expression of the body color occurs rather late, that is, some two weeks after hatching depending on the laboratory conditions and feeding regime ; . Qurt, FLF, and FLFII In both the Qurt strain [26] and FLF strain [27] , the genotypic sex can be identified at early embryonic stages since leucophore differentiation occurs at the 2-day-old embryo stage in the male, but not in the female. This is due to the location of the recessive mutant gene lf ; for the white color in leucophores on the X chromosome and the wild-type allele LF ; in the Y chromosome crossing-over rate of the color marker is rather high, ca. 3 to 4 % ; The Hd-rR.YHNI strain has the orange-red body and SL1 as markers for identification of the genotypic sex [28]. The genotypic sex can be identified accurately because the crossing-over rate of SL1 is almost zero. The FLFII strain was generated by crossing FLF with Hd-rR.YHNI . In the FLFII, the genotypic sex can be screened at early embryonic stages by the presence of leucophores, confirmed at larval stages by the presence of xanthophores, and finally reconfirmed by the PCR marker to eliminate errors in identification using pigment cells [29]. However, the Dmy sex marker may be used for all medaka strains, whereas the SL1 exists only in some specific strains. The FLF strain has been also used for studies of EASs [30]. See-through medaka The see-through medaka is a fish model with a transparent body in the adult stage, as well as during embryonic stages [27]. The main internal organs, namely, heart, spleen, blood vessels, liver, gut, gonads, kidney, brain, spinal cord, lens, air bladder, and gills, in living adult fish are visible to the naked eye or with a simple stereoscopic microscope. Importantly, the see-through medaka will provide an opportunity for noninvasive studies of morphological and molecular events caused by exposure to EASs. Zebrafish Danio rerio ; This tropical species family Cyprinidae ; is native to the Indian subcontinent, is well suited to laboratory culture, and the life cycle is relatively rapid 34 months from embryo hatching to adult breeding at 25 2 Zebrafish are considered to be a gonochoristic-undifferentiated species namely, both juvenile males and females pass through an ovary like stage before differentiating into the phenotypic sex ; . In males, this includes a period of juvenile hermaphroditism, followed by a histological intersex phase with both immature ovaries and testes prior to development of the mature male gonads [31]. This process of oocyte apoptosis in juvenile zebrafish has recently been reported by Uchida et al. [32]. Zebrafish are sensitive to EASs, and there is a growing body of information on the reproductive toxicology of this species [13, 14]. SCREENING FOR POTENTIAL ENDOCRINE ACTIVITY Based on current experience, we propose that the most promising approach to date is the establishment of a new screening protocol adapted from OECD test guidelines 204 and 215. The concept protocol is 2003 IUPAC, Pure and Applied Chemistry 75, 23432353.
Rocaltrol may also be used to treat osteoporosis or other conditions as determined by your doctor.
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