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Chartsri Kuansuwan. Genotyping and E6 E7 mRNA expression of human papillomaviruses in cervical cancer cells. Chiang Mai : Chiang Mai University, 2000. 96 p. T E16260 ; Kulthida Vaeteewoottacharn. Characterization of HPV16 oncogenes : genetic variation, localization and transactivation function. Bangkok : Mahidol University, 2005. 185 p. T E33410 ; Rungkarn Suebsing. HPV-e7-specific immune responses in HPV-infected patients with precancerous and cancerous cervix. Bangkok : Chulalongkorn University, 2004. 132 p. T E29089.
Setting The Netherlands Pharmacovigilance Foundation Lareb maintains the national spontaneous reporting system SRS ; on behalf of the Dutch Medicines Evaluation Board. ADRs are reported by physicians and pharmacists on a voluntarily basis. Reports that are received are subject to review by qualified assessors. Special attention is paid to the description of the ADR. If needed, additional information concerning the clinical details of the report is retrieved. Data concerning the, because fda.
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Institut National de la Sante! et de la Recherche Me! dicale INSERM ; , Unite! 317, Institut Fe! de! ratif de Recherches 31, CHU Rangueil, 31403 Toulouse, France, Departament de Bioqui! mica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, 08028 Barcelona, Spain, and Departament de Bioqui! mica i Biologia ' Molecular, Facultat de Medicina, Universitat Autonoma de Barcelona, Bellatera, Spain.
To use of the study drug and 4 great probability that the adverse event was not likely to be related to use of the study drug. The adverse events noted during the course of this study included nausea, constipation, and diarrhea. However, no adverse events occurring within this pilot were determined as likely to be related to the use of the study drug. The data are presented in accordance with the CONSORT clinical study reporting guidelines as described in the Lancet Moher et al. 2001 ; . Results Study Goals Our primary goal in this initial pilot study was to assess if the study formulation was efficacious in arresting scalp hair loss as well as improving hair quality. Based on anecdotal and open label data, we anticipated being able to show a positive trend demonstrating a response to therapy. The two measurements utilized for this purpose were: 1 ; Investigative staff assessment using a standard assessment format Twenty six [26] male subjects, ages 23 to 64 were enrolled in the trial between July, 1999 and October 1999. Of these 26, nineteen [19] completed the trial. Seven [7] dropped out prior to study completion, with two of these due to a perceived adverse event Table III ; . Five of the seven patients who withdrew did not report an adverse event, but dropped out for reasons unrelated to the research study. A total of 19 patients were evaluated after study completion. Duration of participation in this study ranged from 18 to 24.7 weeks and
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Studies. Eleven healthy volunteer subjects 2 women and 9 men, mean age 35 13 yr ; with normal neurologic and psychiatric histories and examinations were studied under identical condi tions.
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According to the Owens Wiwa 2003 ; account, the Irish and UK ambassadors to Nigeria helped to arrange a meeting between him and the head of Shell in Nigeria, Brian Anderson. They met at the Queen's birthday party. Anderson was unwilling to discuss reparations for environmental damage, but reportedly said he would try to get a fair trial for Ken Saro-Wiwa leader of MOSOP ; , provided that MOSOP issued a statement that "no environmental damage was caused by Shell". When Ken Saro-Wiwa was sentenced to death and executed in November 1995, there was international protest. 15 EU nations recalled their ambassadors from Nigeria. The Heads of state of the British Commonwealth, meeting in New Zealand, suspended Nigeria from the Commonwealth. Yet, no country halted purchase of Nigerian oil, nor sales of oil service equipment. Certainly no western power seriously considered invading Nigeria to bring about regime change. In 1995, Shell was being criticised in the Western media for its unwillingness to put pressure on the totalitarian right-wing regime. NGO's, including Amnesty International, Sierra Club, Greenpeace, as well as activist companies such as the Body Shop campaigned for freedom for the Ogani people and against the human rights abuses. "But these did not stop." O Wiwa, 2003, p41 ; Shortly after, Shell indicated that it would go ahead with plans for a LNG project, "in partnership" with the Nigerian Government. Corporate communications pointed out, correctly, that cancellation of the project will "certainly hurt the 1000s of Nigerians who will be working on the project, and the 10's of 1000's benefiting in the local economy" In May 1997, at the AGM of RDS, 18 Institutional investors tabled resolution that would have required Shell to establish and independent external body to monitor its environmental and human rights policies. Proxy votes from shareholders were 10 to 1 against the resolution. The company reported that it was taking steps internally to reform. It admitted the need for improvement. A massive media campaign was implemented, to change the corporate image to attractive young scientists seeking technological solutions to global problems ; . According to OWiwa "they acknowledged that big companies have social responsibility, and that's a pretty big step for MNCs". Despite the makeover, in 2003, "Internal strife amongst 250 ethnic groups in Nigeria" is still being reported by the global corporate media; but the historic role of corporations, governments and other major players in co-creating the underlying conditions for this "strife" is never mentioned and
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The Workplace Safety and Insurance Board WSIB ; has released its premium rates for 2003. The average rate for 2003 has increased 3% from 2002. The WSIB cited investment market conditions and rising health care costs as the factors precipitating the increase. A chart outlining the WSIB premium rates for 2003 is available on the WSIB website at : wsib.on and
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There are currently two basic types of resistance tests: genotypic and phenotypic tests. Experts recommend a genotypic test if you have recently been infected or have used only a few HIV medications. U.S. HIV treatment guidelines say that for people who have taken a large number of medications, it may be best to take both a genotypic and phenotypic test. Another option is to take what is called a "virtual phenotype, " a type of genotypic test that gives you genotypic results and then plugs these results into a comprehensive database to provide results similar to a phenotypic test. Keep in mind, however, that your doctor may be limited in the number and type of resistance tests he or she can order for you, depending on the clinic's policy and on how you pay for your treatment. Medicaid, private health insurance policies and state HIV AIDS Drug Assistance Programs ADAPs ; may limit coverage to only a few tests a year and may even specify whether a genotypic, phenotypic or a virtual phenotypic test is allowed and
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COMPOSITION: Iloprost 10g ml. PRESENTATION: Nebuliser solution in 2ml glass ampoules. ACTION: Synthetic prostacyclin analogue. INDICATIONS: Treatment of patients with primary pulmonary hypertension, classified as NYHA functional class III, to improve exercise capacity and symptoms. DOSAGE: 2.5g or 5g per inhalation session, administered six to nine times per day, according to individual need and tolerability. CONTRAINDICATIONS: Pregnancy, lactation, severe coronary heart disease, unstable angina, recent myocardial infarction or cerebrovascular events, conditions likely to increase risk of haemorrhage. PRECAUTIONS: Not recommended in patients with unstable pulmonary hypertension with advanced right heart failure. See SPC. SIDE EFFECTS: Very common 10 per cent ; vasodilation, hypotension, increased cough. LEGAL CATEGORY: POM. NET PRICE: 30 624, 100 CONTACT DETAILS: Schering Health Care, The Brow, Burgess Hill, West Sussex RH15 9NE, for example, cycrin.
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Insulin resistance. Growth hormone infusion has been shown to increase plasma insulin concentrations without altering suppression of glucose production and cause insulin resistance in humans due to impairment in effect of insulin in both liver and skeletal muscle 183 ; . In Cushing's syndrome the overproduction of cortisol causes insulin resistance in humans 184 ; . Cortisol overproduction stimulates hepatic gluconeogenesis and increases hepatic secretion of VLDL and decreases the uptake of LDL by the liver, and cortisol-infusion has been shown to induce both hepatic and peripheral insulin resistance 185, 186 ; . Plasma glucagon, cortisol and growth hormone responses to insulin-induced hypoglycemia are impaired in patients with type 2 diabetes 187 ; . 2.2.1.9. Other causes Hypophosphatemia causes insulin resistance and is associated with hyperinsulinemia and impaired glucose tolerance 188, 189 ; . Acute ethanol administration induces insulin resistance 190, 191 ; . Several electrolyte disturbances such as hypercalcemia 189, 192 ; , hypokalemia 193 ; , hypomagnesemia 194 ; , and several medications such as diuretics 195 ; , non-selective -blockers 196 ; , protease inhibitors 197 ; , and cyclosporin 198 ; cause insulin resistance. Androgens have been implicated to contribute to the insulin resistance that is often present in a polycystic ovary syndrome PCO ; 199 ; . In addition, a positive family history of type 2 diabetes may increase the susceptibility to insulin resistance 126 ; . 2.2.2. Mechanisms 2.2.2.1. FFA Plasma FFA concentrations are elevated in obesity 101, 200, 201, ; and often in type 2 diabetes 203, 204 ; . High levels of circulating FFA have been suggested to provide a link between obesity, type 2 diabetes and insulin resistance. Infusion of FFA increases hepatic GNG in normal subjects and in patients with type 2 diabetes, but due to autoregulation EGP remains unchanged 205, 206 ; . Raising plasma FFA concentrations by lipid infusion counteracts insulin-induced suppression of EGP and induce hepatic insulin resistance 207, 208, 209, ; . Under these conditions insulin inhibition of GL appears to prevent hepatic autoregulation. Increased levels of plasma FFA concentrations inhibit insulin-stimulated glucose uptake by decreasing glycogen synthesis and carbohydrate oxidation 208, 209, 211, ; . Reduced glycogen synthesis is associated with decreased glucose-6phosphate levels suggesting that FFA impair glucose transport or phosphorylation 213 and
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Delivered the samples to the police department's evidence custodian. Although the defendant objected when Taylor testified that the samples were sent to the TBI laboratory, the trial court allowed Taylor to testify that the custodian sends the samples to the lab. The evidence custodian did not testify, and no one testified that the samples brought in by Taylor were the same ones sent to and received from the lab. Nevertheless, the defendant failed to object when the lab analysis reports were admitted into evidence. The defendant asks that the failure to require the state to establish a chain of custody be reviewed as plain error. See Tenn. R. App. P. 36 a Tenn. R. Crim. P. 52 b.
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Evaluation of current and past substance use is an important component of STI risk assessment see Primary Care and Sexually Transmitted Infections chapter ; . Table 1 outlines the six main elements of a substance use history, including sexual risk associated with substance use and possible questions for each element. The word use carries no value judgment, but abuse does. Asking about substance use is more likely to lead to an open, honest answer. Elicit information on legal drug use, illegal drug use and harmful use of drugs sold for medicinal purposes. When assessing substance use as part of the STI risk assessment, use language that will be easily understood. Becoming familiar with the terms used in your region can help you to effectively communicate. Table 2 provides a quick reference for frequently used substances, street names and possible modes of delivery and
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F. Othmer. To be published in 12 volumes, New York: American Druggist, 1953. 11 published by 1953. New York: Inter- THE BRITISH PHARMACEUTICAL CODEX, 1949. ; . science, 1947Pharmaceutical Society of Great Britain. TRADE NAMES INDEX. New York: Special London: The Pharmaceutical Press, 1949. Libraries Association, 1946. 1952 SUPPLEMENT THE BRITISH PHARMATO HANDBOOK MATERIAL OF TRADENAMES. By CEUTICAL CODEX, 1949. Pharmaceutical So0. T. Zimmerman and Irvin Lavine. Dover, ciety of Great Britain. London: The PharN. H.: Industrial Research Service, 1953. maceutical Press. TECHNICAL LIBRARIES, THEIRORGANIZATION DRUG TOPICS RED BOOK. 1954. New York: AND MANAGEMENT. Edited by Lucille JackTopics Publishing Company. son. New York: Special Libraries Associa- FACTSAND COMPARISONS. Edited by Erwin K. tion, 1951. Kastrup. St. Louis, Mo.: Facts & CompariLIST O PERIODICALS F ABSTRACTED CHEMBY sons, 1953. Monthly revisions ; ICAL ABSTRACTS WITH KEY TO LIBRARY GEHE'S CODEX. 7th ed. Dresden, Germany: FILES AND OTHER INFORMATION. American Schwarzick-Verlag, 1937. Chemical Society. Columbus: The Ohio GREENBOOK 1953-1954, BUYERS'DIRECTORY. State University, 1951. Issued by Oil, Paint and Drug Reporter. UNION LIST OF PERIODICALS IN PHARMACEUT- New York: Schnell Publishing Company. ICAL LIBRARIES. Edited by Gertrude Bloom- THE MERCK INDEX O F CHEMICALS AND er. New York: Special Libraries Association, DRUGS. 6th ed. Rahway, N. J.: Merck & 1952. Company, 1952. A SHORT GUIDE TO CHEMICALLITERATURE. MODERNDRUG ENCYCLOPEDIA AND THERABy G. M. Dyson. London: Longmans, 1951. Edited by Marion E. HowPEUTIC INDEX. MEDICALWRITING, THE TECHNICAND THE ard. New York: Drug Publications, 1952. ART. By Morris Fishbein. Philadelphia: Supplements published every two months. ; Blakiston, 1950. THE NATIONAL FORMULARY. Commit9th ed. OF SCIENTIFIC BIBLIOGRAPHY INTERLINGUAL tee on National Formulary. American PharAND TECHNICAL DICTIONARIES. By J . maceutical Association. Easton, Pa.: Mack Holmstrom. 2nd ed. Paris: UNESCO, 1951. Publishing Company, 1950. NEW AND NONOFFICIAL REMEDIES, 1953. Pharmacopoeias, Dispensatories and Council on Pharmacy and Chemistry. American Medical Association. Philadelphia: Additional Drug Sources Lippincott, 1953. BRITISH PHARMACOPOEIA Published 1953. FOR NEW AND NONunder the direction of the General Medical TESTS AND STANDARDS OFFICIAL REMEDIES, 1953. Issued by The Council. London: The Pharmaceutical Press, Chemical Laboratory. American Medical 1953. THE EXTRAPHARMACOPOEIA MARTINDALE ; . Association. Philadelphia: Lippincott, 1953. DESK REFERENCETO PHARMAVol. 1, 23rd ed. Published by direction of PHYSICIANS CEUTICAL SPECIALTIESAND BIOLOGICALS, the Council of the Pharmaceutical Society 1953. 7th ed. Rutherford, N. J.: Medical of Great Britain. London: The PharmaEconomics, 1952. ceutical Press, 1952. DRUGS.Pharmaceutical Section, SciPHARMACOPOEA INTERNATIONALIS. Editio Pri- UNLISTED ence-Technology Division, Special Librama. Volumen I. International Pharmaries Association. New York. Vol. 1, 1949 to copoeia. 1st ed. Vol. I ; Geneva: World date. Issued monthly. Health Organization, 1951. THE PHARMACOPEIA UNITED STATES THE 1952 YEAR BOOK OF DRUG THERAPY. OF THE Chicago: The Year Book Publishers, 1952. OF AMERICA. 14th rev. ed. United States Pharmacopoeia1 Convention, Inc. Easton, Extensive Treatises by Subject Pa.: Mack Publishing Company, 1950. ALKALOIDS THE DISPENSATORY THE UNITED STATES OF THE ALKALOIDS CHEMISTRY AND PHYSIOLOGY. OF AMERICA.Vo1. 1 and 2. Edited by Ar1, Vol. I, 1950; Vol. 11, 1952; Vol. 1 1953; thur Osol and George E. Farrar, Jr. 24th Vol. 1V and V will complete series. By ed. Philadelphia: Lippincott, 1950. R. H. DICTIONNAIRE SPECIALTES PHARMACEUTIQUES. F. Manske and H. L. Holmes. New York: Academic Press. Paris: Office de Vulgarisation, 1950.
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Most of our current understanding of the epidemiology of C. pneumoniae infection derives from serologic studies using the microimmunofluorescence assay MIF ; . These studies indicate that C. pneumoniae infection is common throughout the world. Seropositivity is low in early childhood 5 years ; , rising rapidly during school years. At the age of 20 years, approximately 50% of individuals will have detectable antibodies. Seroprevalence continues to rise, albeit at a slower pace, in adulthood and reaches 75% in the elderly population20, 22. This high antibody prevalence in later life suggests that reinfection with the organism is common. Seroprevalence is approximately.
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In this study it is observed that cavitary lesion in chest x-ray and close contact with tuberculosis were found to be risk factors for development of drug resistance, for example, drugs.
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