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The potential for prevention and therapy, with limited risk of systemic uptake, side effects, and drug interaction, makes local delivery of various medications to mucosal tissues desirable. In addition, local administration can supplement systemic delivery of medication.The oral mucosa, gingiva, and dentition are accessible to topical therapies, but vehicles and forms of delivery of various agents need to be developed and assessed in cancer patients. Forms of delivery include topical gels or creams, rinses, lozenges, and chewing gum. Considerations in development of topical products for cancer patients include texture and viscosity of the product, taste, stability, and shelf life. Patients receiving cancer therapy require assessment of the vehicle, as oral pain, nausea, and enhanced gag reflexes may affect compliance.93 Taste may change during the course of cancer therapy and taste aversions can develop. Therefore, clinical trials must be conducted in the target population. Future drug development of topical agents will enhance the ability to prevent and treat oral complications of cancer and cancer therapy. Related products: 8-mop , meladinine , metoxalen , oxsofalen , oxsoralen-ultra , ultra mop , uvadex , xanthotoxin , methoxsalen generic name and noroxin.
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