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Small number, and it can be misleading. The number of deaths included non-breast cancer deaths, and in both groups the vast majority of deaths were not due to breast cancer. Actually, to date, only 5 women in the study have died of breast cancer. What about side effects? Women on Arimirex had fewer of the side effects long associated with Tamoxifen, like hot flashes, weight gain and vaginal dryness. What was unexpected, and important, though, is that the women on Qrimidex had a higher rate of bone fractures. The bottom line: Tamoxifen is a known quantity. Much more remains to be learned about Arim8dex and its use in the adjuvant setting. It took many years and a number of research studies to determine that women benefit most if they take Tamoxifen for five years. We don't know how many years women should stay on A4imidex to gain the most benefit. We also don't know if there will be any negative side effects if women stay on these drugs for a long time. Because Arimieex out-performed Tamoxifen in the metastatic setting, some post-menopausal women with early stage breast cancer and their physicians are choosing to go ahead and try it in the adjuvant setting. Women who make this choice should be monitored carefully by their physician, especially for early signs of osteoporosis. News on Herceptin Herceptin, a monoclonal antibody designed to fight tumors that are HER2 neu positive, is currently only FDA-approved for use in women with metastatic disease. But research is underway to evaluate the drug's safety and effectiveness in the adjuvant after surgery ; setting in women with early stage breast cancer. Herceptin alone can increase the risk of a woman developing heart toxicity. The risk is even higher when Herceptin is used in conjunction with Adriamycin Doxorubicin ; . This is significant because Adriamycin is one of the most common forms of chemotherapy used for adjuvant therapy. It also raises questions about what the best treatment will be for women with early stage breast cancer who have HER2 neu-positive tumors. For women with early stage breast cancer, the risk of heart toxicity matters more because surgery alone may have cured their disease. For women with metastatic disease, the heart toxicity matters less because the benefit of the drug outweighs the risk. The information presented in San Antonio on Herceptin in the adjuvant setting was a pilot trial conducted by the Eastern Cooperative Oncology Group. The trial E2198 ; looked at whether giving Herceptin before giving Adriamycin rather than giving it concurrently ; would be a better option. All of the women in the pilot trial were lymph-node positive and had no prior history of heart problems. They were divided into two treatment arms. In Arm A the women received Paclitaxel Taxol ; and Herceptin for four cycles. After a three week break they received four cycles of Adriamycin and Cyclophosphamide Cytoxan ; , known as AC. The women in Arm B had the same regimen but then went on to receive Herceptin for 52 weeks.

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Inactivity. The less active you are, the greater your risk of diabetes. Physical activity helps you control your weight, uses up glucose, makes your cells more sensitive to insulin, increases blood flow and improves circulation in even the smallest blood vessels. Exercise also helps build muscle mass. Thats important because most of the glucose in your blood is absorbed into your muscles. When you have less muscle tissue, more sugar stays in your blood. Age. Your risk of type 2 diabetes increases as you get older -- especially past the age of 45. Often, thats because people tend to exercise less, lose muscle mass and gain weight as they age, and because more often than not, weight gain involves a diet high in carbohydrates and fat. But diabetes is also increasing dramatically among younger people -- especially those in their 30s and 40s. Race. For reasons that arent entirely clear, people of some races are more likely to develop diabetes. Approximately 6 percent of the general population has diagnosed diabetes. But that rate doubles for blacks and Hispanics and more than doubles for American Indians. Among the Pima Indians of Arizona, half of all adults have type 2 diabetes -- one of the highest rates of diabetes in the world. Type 1 diabetes, on the other hand, is more common in white Americans and in European countries such as Finland and Sweden. When to seek medical advice See your doctor right away if you notice any of the signs and symptoms of diabetes, especially increased thirst and urination. And if you have diagnosed diabetes, get regular checkups to monitor your condition. How often you see your doctor or other members of your health care team for checkups depends on how well youre doing. If youre having trouble keeping your blood glucose levels down or if youre changing medication, you may need to contact a member of your health care team every week. Your doctor may even recommend that you stop in daily until your blood sugar level stabilizes. But if youre feeling well and keeping your blood sugar within the range you and your doctor have agreed on, you probably wont need checkups more than once every three months, because pregnancy.

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HISTOPATHOLOGICAL ASPECTS OF STEATOHEPATITIS A.V. Ditoiu, 0. Motoi, V. Herlea * , M. Hortopan * Fundeni Hospital, Medical & Hepatology Clinic, * Department of Pathology Bucharest, Romania The simple steatosis S ; can progress to steato hepatitis and then to chronic hepatitis CH ; . Methods: We studied the presence of lipid inclusions in liver specimens obtained by liver biopsies of 104 patients pts ; with CH HBV 54 pts ; or HCV 60 pts ; . The specimens were embedded in paraffin and stained with hematoxylin - eosin, van Gieson and Perls then was examined in optical microscopy. The histopathological evaluation was made by lshak score. We excluded the main causes of hepatic steatosis: alcohol, drugs, obesity and diabetes mellitus. Results: S was found in 40 pts, 38.4% of cases ; - 33pts 30% ; with HCV CH and 8pts 20% ; with HBV CH -. In pts with HCV CH, steatosis was found in 53.3% of cases, sometimes associated with biliary duct lesions 12.5% of cases ; or lymphoid follicles 22.5% of cases ; . As compare CH steatosis group vs. CH non - steatosis group, we found: piecemeal necrosis 47.5% vs. g2.8% cases, intralobular inflammation with mononuclear cells 77.5% vs. 90.8% cases, Kupifer cells hyperplasia 15% vs. 18.4% cases. The evaluation of S was made in three stages: st I - 72.5% of cases, st II - 20% of cases and st III - 7.5% of cases. The relationship between S and Ishak score was: Steatosis Medium index activity Medium fibrosis index StI 6.3 2.1 StIl 5.57 1.7 St III 8.5 4.5 The hepatocytes regeneration was found in st I steatosis only. Conclusions: steatosis, present in 53.3% cases of HCV CH and only in 12.5% cases in HBV CH is less frequent associated with piecemeal necrosis and intralobular inflammation with mononuclear cells than CH without S. The hepatocytes regeneration is found only in st I steatosis but, in st Ill of steatosis we found the highest activity and fibrosis index, this last stage being probable followed by CH. Adress.

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Table 1. Spermidine contents of ribosomes isolated from brain-cortex slices after various treatments The treatments of brain-cortex slices, isolation of ribosomes and determination of spermidine were as, for instance, .

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