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P167 Preliminary study of combined action of a furoquinolinone FQ ; and 311 nm narrowband UVB R. Bevilacqua, F. Baccichetti; Dept. of Pharmaceutical Sciences of Padova University, Padova, Italy. The versatility of PUVA with respect to choice of psoralens or analogous, mode of application, and irradiation protocols ; gives it the advantage of being continuously developed and adapted in order to fit disease-specific needs optimally. The photocarcinogenic hazard of high cumulative doses of PUVA has increased the interest in modifications of existing protocols which may reduce long-term risks. At the same time the narrowband UVB source has expanded phototherapeutic alternatives. 1, 4, 6, FQ ; , one of the most interesting compounds synthesized in our Department, has antiproliferative activity even in the dark, unlike the furocoumarins 8-MOP and 4, 6, 4'-TMA. Coupled with 311 nm narrowband UVB irradiation, it could enhance the own therapeutic activity. In PUVA, treatment by mouth is currently favoured, since it produces fewer toxic side-effects. However, results obtained with this type of administration are greatly influenced by uncontrollable factors wich affect the velocity of absorption, particularly by organs. In order to overcome this disadvantage, we evaluated the quantity of furoquinolinone in sera and organs of healthy and tumor-bearing animals in the dark and under narrowband UVB, using the i. p. pathway, for example, avodart info product.
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FACT SHEET ON THE LATEST SCIENCE LINKING USE OF ANTIMICROBIALS IN ANIMAL AGRICULTURE TO INCREASING ANTIMICROBIAL RESISTANCE IN HUMANS March, 2003 There is an emerging scientific consensus that overuse of antimicrobials in animal agriculture contributes to antimicrobial resistance that is transmitted to humans. In 2000 the Alliance for the Prudent Use of Antibiotics APUA ; convened a Scientific Advisory Panel consisting of experts from human and veterinary medicine, public health, microbiology, biostatistics, and risk analysis. Over the course of two years the Panel conducted a comprehensive review of over 500 of the latest scientific studies on the human health impacts of antimicrobial use in agriculture. The Panel's report appeared as a supplement to the peer-reviewed journal Clinical Infectious Diseases in 2002. Publication of this report was a seminal event, compiling and bringing together in one document disparate scientific and medical evidence. This fact sheet will draw upon the APUA report, as well as other studies published contemporaneously or subsequent to that report. There are several lines of evidence linking antimicrobial use in agriculture to resistant infections in humans, including the following. 1. Direct epidemiological evidence tracing resistant human infections to specific livestock and poultry operations.
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Because of the potential problem of background interference, and the relatively high cost associated with collecting and analyzing indoor air samples, the use of indoor air concentrations may not be the most practical way to evaluate the effectiveness of a cleanup. Sampling surfaces for meth may be a more practical tool to gage the effectiveness of cleanup. If indoor air sampling is conducted, it should be performed by an environmental professional, familiar with indoor air sampling techniques, that is capable of interpreting the data and evaluating the potential for background interference. Prior to collecting an indoor air sample for VOCs, the indoor air temperature should be maintained at 70 degrees Fahrenheit or above for a minimum of 24 hours. Indoor air should be sampled for chemicals determined to be part of the lab site chemical inventory developed as part of the preliminary assessment ; and in consultation with the local health department, or other oversight agency. Sampling and testing should be performed using recognized standards and written procedures designed to ensure accuracy, reproducibility, and relevance to onsite contamination. Written documentation showing that the cleanup has been completed should be submitted to the local health department, or other agency overseeing the cleanup. The final report should summarize the work performed, present data collected during the post-cleanup assessment, and be signed by a Certified Industrial Hygienist, or other qualified environmental professional. The local health department, or other oversight agency, may review the report and determine whether the property is suitable for re-occupancy. RE-OCCUPANCY OF STRUCTURES In order to determine acceptable risk-based concentrations for meth lab related chemicals, the Department reviewed human exposure reference values for chemicals commonly associated with meth production. This evaluation included acute based on high-level, short term exposures ; , and chronic based on low-level, long-term exposures ; minimum risk levels. Acute minimum risk levels may be useful for evaluating high-level exposures, such as those associated with the meth cooking process or direct exposure to meth related chemicals prior to gross cleanup as described previously ; . Chronic minimum risk levels may be appropriate for evaluating long-term exposure to residual levels of meth related chemicals, after gross cleanup has been conducted. Therefore, chronic minimum risk levels were used to develop proposed exposure limits for residual meth lab related chemicals, as shown in Table 2. The evaluation process used to develop the proposed exposure limits is described in Attachment 2. Acute exposure limits from the NIOSH Pocket Guide are provided in Table 1 for select meth lab related chemicals. Several other states have established cleanup standards specifically for the residue of meth. After communicating with some of these state health departments, it was learned that these levels are not health-based. The meth cleanup levels are based on what is believed to be conservative and protective, while at the same time achievable by clean-up contractors. Currently, there is not sufficient information available regarding the effects of long-term exposure to low concentrations of meth to adequately evaluate chronic minimum risk levels. Therefore, the Department is unable to provide a health-based exposure limit for meth at this time. As discussed previously, there are difficulties related to testing and evaluating the concentrations of meth related chemicals in indoor air. Therefore, the use of meth testing to evaluate the effectiveness of cleanup may be more practical than the use of indoor air concentrations of other associated chemicals. In order to provide a practical measurement to determine the adequacy of cleanup, the Department. 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