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Pongrac, Julie Wang X, Pongrac JL, DeFranco DB. 2002 ; . Glucocorticoid receptors in hippocampal neurons that do not engage proteasomes escape from hormonedependent down-regulation but maintain transactivation activity. Mol Endocrinol, 16: 1987-1998. Pongrac JL, Middleton FA, Lewis DA, Levitt P, Mirnics K. 2002 ; . Gene expression profiling with DNA microarrays: advancing our understanding of psychiatric disorders. Neurochem Res, 27: 1049-1063. Raymond, Lynn Zeron MM, Hansson O, Chen N, Wellington CL, Leavitt BR, Brundin P, Hayden MR, Raymond LA. 2002 ; Increased sensitivity to N-methyl-D-aspartate receptor-mediated excitotoxicity in a mouse model of Huntington's disease. Neuron, 33: 849-860. Li B, Chen N, Luo T, Otsu Y, Murphy TH, Raymond LA. 2002 ; . Differential regulation of synaptic and extrasynaptic NMDA receptors by calcium and tyrosine phosphorylation. Nature Neuroscience, 5: 833-834. Krebs C, Fernandes HB, Sheldon C, Raymond LA, Baimbridge KG. 2003 ; . Functional NMDA receptor subtype 2B is expressed in astrocytes following anoxia ischemia both in vivo and in vitro. J Neuroscience, 23: 3364-3372. Reebye, Pratibha Reebye PN, Morison S, Panikkar H, Misri S, Grunau RE. 2002 ; . Affect expression in prenatally psychotropic exposed and nonexposed mother-infant dyads. In Infant Mental Health Journal, 234: 403-416. Reebye PN, Worling D. 2002 ; . [Letter] Gestational Diabetes Mellitus GDM ; in a sample of children referred for disruptive behaviour disorders. The Canadian Child Psychiatry Review, 11 2 ; : 13. Scamvougeras, Anton Scamvougeras A. 2002 ; . Challenging Phenomenology in Tourette's Syndrome and Obsessive-Compulsive Disorder: The Benefits of Reductionism. Canadian Journal of Psychiatry, 17-19. Scamvougeras A, Kigar DL, Jones D, Weinberger DR, Witelson SF. 2003 ; . Size Of The Human Corpus Callosum Is Genetically Determined: An MRI Study In Mono And Dizygotic Twins. Neuroscience Letters, 338: 91-94.

Through the establishment of a fund in honour of the 50th birthday of his wife, Corey Simpson, Mr. Terrence J. O'Sullivan, Chair of the Sunnybrook Foundation Board of Directors, inspired the Norman and Margaret Simpson Garden Pavilion in the Veterans residence. Both of Ms. Simpson's parents received care at Sunnybrook. Mr. Simpson was a WWII naval commander and Veterans Care resident; Mrs. Simpson, an avid gardener, had been cared for through her diagnosis with Alzheimer's. After both parents had passed away, the family thought it was fitting to honour their memory by supporting patients with similar life experiences, improving the services the hospital is able to provide to them as residents. "It was our hope that we could provide something to recognize the contributions of veterans to society, and provide a place of enjoyment for cognitive patients in their later years. In doing so, we honour my mother-in-law, a woman who loved gardening, and my father-in-law, a remarkable veteran, " said Mr. O'Sullivan. The Foundation is deeply honoured by the O'Sullivan Simpson family's benevolence towards our veteran community. Special thanks to: the facilities planning department, and Bruce Carter and his crew for executing a very successful design and renovation and aciphex. A24 CAN BOTULINUM TOXIN IMPROVE GAIT IN PERSONS WITH INCOMPLETE SPINAL CORD INJURY? Christine Short MD, FRCPC, Division of Physical Medicine and Rehabilitation, Dalhousie University, Halifax, NS. Objective: To evaluate the effect of botox on ambulation capabilities in persons with incomplete Spinal Cord Injury SCI ; . Background: Spinal Cord Injury can have devastating impacts on function. Many individuals who suffer incomplete SCIs regain the ability to ambulate. These individuals face many challenges including spasticity, which can interfere significantly with walking capabilities. In SCI, spasticity in individual muscles or muscle groups may cause problems with gait and ambulation that may be amenable to local tone reducing therapies such as botulinum toxin. Methods: In 4 patients presenting with spastic gait and SCI we administered botulinum toxin to one or both lower extremities. Ambulation parameters before and after treatment were assessed using a well, validated ambulation profile tool developed at our centre. Results: We observed improvements in ambulation speed, ambulation on uneven surfaces, ability to ascend and descend inclines and stairs; as well as overall improvements in total ambulation capability. Post treatment this allowed two of our subjects to become independent in walking related activities that they required assistance for prior to treatment. Subjectively individuals also reported improved clonus, decreased tone, decreased pain and greater ease of ambulation. Conclusions: Botulinum toxin may have an important role in improvement of ambulation capabilities in persons with incomplete SCI. Further research in this area is needed.
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Sobhonslidsuk A, Roongpisuthipong C, Nantiruj K, Kulapongse S, Songchitsomboon S, Sumalnop K, Bussagorn N. : Impact of liver cirrhosis on nutritional and immunological status. : Journal of the Medical Association of Thailand. 84 7 ; : 982-8, 2001 Jul ; . : Liver cirrhosis, Nutritional, Immunological status, Protein calorie malnutrition, PCM, Subjective Global Assessment, SGA. : The aims of the study were to determine the prevalence of protein calorie malnutrition PCM ; in Thai cirrhotic patients and to evaluate nutritional and immuno.
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Epithelial and mesenchymal mitogens stimulate VEGF expression in cultured dermal papilla cells U Kozlowska, 1 U Blume-Peytavi, 2 C Sommer, 2 CE Orfanos, 2 S Jablonska1 and S Majewski1 1 Dermatology, Warsaw Medical School, Warsaw, Poland and 2 Dermatology, University Medical Center B. Franklin, Free University of Berlin, Berlin, Germany Vascular Endothelial Growth Factor VEGF ; acting selectively on endothelial cells induces angiogenesis and enhances vascular permeability. In previous studies we found, that human cultured dermal papilla cells synthesize VEGF, implicating its role in hair vascularisation. Moreover VEGF synthesis was influenced in vitro by addition of proinflammatory cytokines suggesting possible link between vascular supply and the development of inflammatory processes involving human hair follicle. The aim of this study was to find the relationship between hair cycle regulating growth factors and VEGF synthesis from hair papilla. Several growth factors: EGF, TGF, TGF-1, bFGF, PDGFaa, IGF-1 and NGF, mitogens for various epithelial and mesenchymal cells and influencing hair growth cycle were investigated for their effect on VEGF gene expression and protein synthesis in cultured dermal papilla cells. VEGF mRNA expression was measured by semiquantitative RT-PCR method and VEGF proteins by radioimmunoprecipitation. Growth factors known to be promoters of angiogenesis like TGF1, PDGFaa as well as anagen-promoting IGF-I significantly stimulated VEGF mRNA expression in dermal papilla cells. The highest VEGF mRNA levels in DPC were observed after stimulation with EGF and IGF-1 after 2 hours. Hair cycle-dependent vascular changes are probably regulated by the same cytokines and growth factors, which control hair growth cycle, and are synchronized with the growth of other follicular structures. The investigation of VEGF expression in DPC in vitro may serve as a model of influencing angiogenetic processes associated with human hair follicle, and therefore might be potentially useful in finding new treatment options of alopecia.

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