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Application for Inquiry: Eligibility and Grounds 4. I a Canadian resident older than eighteen years of age and of the opinion that grounds exist for the making of an order under Part VIII of the Competition Act. 5. In recent years, some Canadian brand name pharmaceutical companies have aggressively pursued strategies aimed at extending market monopolies for certain blockbuster drugs1 and at delaying consumer and patient access to lower-priced, therapeutically equivalent generic drug products. 6. One such strategy, called "evergreening" involves obtaining multiple patents relating to the same basic drug product, listing these patents on the Canadian Patent Register, and obtaining successive 24-month stays of regulatory approval of generic products. 7. Evergreening artificially extends the patent life and market monopoly of the brand name drug and delays or even prevents ; market entry of independent generic products. The obvious effect is a substantial prevention or lessening of competition in the pharmaceutical market. 8. Of particular concern to myself and the National Union of Public and General Employees is the fact that there is no remedy whatsoever to compensate Drug Purchasers when entry of a generic drug is unnecessarily delayed. 9. This matter is of grave concern to all Canadians. I have been mandated by our members to contact you to pursue this issue. We are prepared to take all necessary means to support your inquiry into these anticompetitive brand name monopoly extension strategies and help stop the ongoing economic harm being caused to all Canadians. 10. The practice of evergreening constitutes an offence under section 79 of the Competition Act. Accordingly, we make this application for inquiry under section 9 1 ; of the Competition Act. Below, I set out the specific grounds for the making of an order under Part VIII of the Competition Act. Background: Access to Affordable Medicine 11. The increasing cost of pharmaceuticals and access to affordable medicine have become important issues in Canada. For example, in the 20-year period between 1979 and 1999 there was an increase from 8.6% to 15.2% in the percentage of overall health care spending attributed to drugs. By 1997, drug costs including prescription and non-prescription drugs ; had overtaken spending, because allegra comtessa.
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INDEX 8-Mop .39 A A B otic.16 Abilify.28 Accolate.33 Accuzyme .40 Acebutolol .20 Aceon .22 Acetaminophen Codeine .29 Acetasol .16 Acetasol HC .16 Acetazolamide .21 Acetic acid . 16, 29 Acetic acid Aluminum.16 Acetic acid Hydrocortisone.16 Acetohexamide .9 Acetylcysteine .34 Acid jelly.37 Acidic vaginal .37 Aciphex .15 Aclovate.9 Acthib.7 Acticin.26 Actimmune.7 Actiq.29 Activella.11 Actonel .11 Actos .9 Acular .18 Acular LS .18 Acular PF .18 Acyclovir.26 Adderall XR .6 Adoxa .25 Advair diskus .33 Advanced natalcare .40 Advanced-Rf natalcare.40 Advicor.22 Aero Otic HC .16 Aerobid.33 Aerobid-M .33 Aerohist.34 Aerohist plus.34 Afeditab CR .20 Agenerase .27 Aggrenox. 19 Ak-Con. 16 Ak-Dilate. 17 Akineton . 6 Akne-Mycin. 37 Ak-Pentolate. 17 Ak-Poly-Bac . 17 Aktob. 17 Ak-Trol . 18 Alamast. 17 Ala-Scalp HP. 9 Albalon . 17 Albenza . 26 Albuterol. 33 Albuterol sulfate . 33 Albuterol sulfate HFA. 33 Alclometasone dipropionate . 10 Alcortin. 38 Aldara . 8 Alinia . 26 Alkabel SR . 14 Alkeran . 7 Allclenz . 40 Allegda . 32 Allegra-D 12 hour. 32 Allegra-D 24 hour. 32 Allergen . 16 Allerx . 34 Allopurinol. 31 Alocril . 17 Alomide . 17 Alora . 11 Alphagan P . 18 Alprostadil .11, 41 Alrex . 18 Altace. 22 Altex-PSE. 34 Altoprev . 22 Aluminum chloride . 37 Alupent . 33 Amantadine .6, 27 Amaryl . 9 Ambi 1000 55 . 34 Ambien . 7 Ambifed-G . 34 Amcinonide . 10 Amdry-C. 34 Amerge.5 Amibid LA. 34 Amicar. 19 Amidrine .5 Amigesic. 31 Amikacin sulfate . 23 Amiloride . 21 Amiloride HCTZ . 21 Amino acid cervical. 37 Aminocaproic acid . 19 Aminophylline. 33 Amiodarone. 20 Ami-Tex LA . 34 Ami-Tex PSE. 34 Amitriptyline . 27 Amitriptyline Perphenazine. 27 Ammonium lactate . 37 Amnesteem. 39 Amox TR Potassium clavulanate . 24 Amoxapine . 27 Amoxicillin . 24 Amoxil 250 mg ml suspension. 24 Amoxil 500 mg capsule. 24 Amphetamine salt combo .6 Amphotericin B. 25 Ampicillin trihydrate . 24 Ampicillin-Sulbactam. 24 Anabar. 31 Anagrelide . 19 Analpram-HC . 38 Anaspaz . 14 Ancef. 24 Ancobon. 25 Andehist . 34 Androderm . 11 Androgel. 11 Android . 11 Androxy. 11 Anemagen OB. 41 Anexsia. 29 Antabuse. 28 Antara . 22 Anthralin . 39.
8.5 There are Disadvantages of OTC Dominance 8.6 Generic Companies Will Target Allergic Rhinitis Treatments 8.7 The OTC Decision is Key for the Allergic Rhinitis Market 8.7.1 US Authorisation for OTC 8.7.2 OTC Status in Other Countries 8.7.3 Considerations for the OTC Decision in the Allergic Rhinitis Market 8.7.4 Timing is Everything in the Anti-Allergy Markets 8.8 Unmet Needs: Persistent Sufferers Require Reliable and Convenient Treatments 9 Future Developments 9.1 New Takes on Established Treatments Will Help Stem the Tide After Patent Loss 9.1.1 Schering Plough and Merck Invest in Combination Therapy 9.1.2 GSK Attempts to Emulate Nasonex's Success 9.1.3 Is efletirizine Zyrtec's True Successor? 9.2 Immunotherapy Aims to Meet Unmet Needs 9.2.1 Grazax 9.2.2 Pollinex-Quattro 9.2.3 Curalogic Three `vaccines' at Phase II or above 9.2.4 Cytos' QbG10 Technology May Offer Allergen Independent Relief 9.3 Development of New Asthma Treatments Will Lead to a New Allergy Drugs 9.3.1 From Proteins to Oligos A Variety of Modes of Action 9.3.2 MAbs May Prove Technically Difficult and Expensive 10 Other Allergy Drugs 10.1 Allergic Conjunctivitis 10.2 Atopic dermatitis 10.2.1 The Market for Topical Eczema Treatments is Small and Shrinking 10.2.2 Non-steroidal Treatments Lead the Prescription Market 11 Conclusion: A Mature Market in Need of Innovation 11.1 The Allergy Market is Divided Into Sub-markets 11.2 OTC May be the Answer For Some But Not All 11.3 The Use of Vaccines is Set to Increase List of Figures Figure 3.1, Total Revenues $m ; for the Top Ten Allergic Rhinitis Treatments, 20042005 Figure 3.2, Growth Rates % ; for the Top Ten Allergic Rhinitis Treatments, 20042005 Figure 3.3, Allergic Rhinitis Market Share by Brand, 2005 Figure 3.4, Allergic Rhinitis Market Share by Mode of Action, 2005 Figure 3.5, Growth Rates % ; for Allergic Rhinitis Treatments by Mode of Action, 2004-2005 Figure 3.6, Total Schering Plough Revenues for Claritin, 2002-2005 Figure 5.1, Market Share by Drug for Antihistamines, 2005 Figure 5.2, World Revenues for Prescription Antihistamines, 2004-2011 Figure 5.3, Revenue Forecast for Zyrtec, 2005-2011 Figure 5.4, Revenue Forecast for Allegra, 2005-2011 Figure 5.5, Revenue Forecast for Clarinex, 2005-2011 and amaryl.
Smoking is a major risk factor for heart disease, stroke, and cancer, and is the leading preventable risk factor of death in adults. In the past few decades, though, the rates of smoking have been declining. In 1965, 41.9% of adults 18 and older smoked; in 1998, only 24.0% of adults were current smokers or smoked on "some days." Source: Center for Disease Control Fact Book for 2000-2001, Atlanta, GA, p. 47 : cdc.gov maso factbook main, for instance, alleggra dance studio.
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