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Novel therapies to treat breast cancer, HIV and hepatitis B infections are generating encouraging results for GlaxoSmithKline. Recent trial data have revealed that lapatinib GW572016 ; can stabilise and halt progression of metastatic breast cancer tumours that do not respond to trastuzumab Herceptin ; . Lapatinib is a potent inhibitor of both ErbB1 and ErbB2; two receptors frequently over-expressed in human tumours. Phase II clinical trials of lapatinib have been carried out in 41 patients to date, and have shown that metastatic tumours in 17 per cent of patients did not progress with continuing lapatinib therapy at 24 weeks. The trial will continue in a total of 80 patients and phase III trials in patients with advanced metastatic breast cancer have now started. Another drug being developed by GSK, for treatment of HIV infection, has shown promise in a phase II study designed to evaluate its short-term safety, tolerability and efficacy. The investigational compound 873140 is one of a new class of drugs that block CCR5 receptors to prevent binding and entry of HIV into target cells. Patients.

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