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Amorfix Life Sciences Ltd. TSX-V: AMF ; , Toronto, Ontario Business: Diagnostic, Neurology Transition: CSO Neil Cashman from chairman of AMF to chairman of AMF's scientific advisory board; Michael Sonnereich, president and CEO of Global Communications Corp. Ltd. Bio-Rad Laboratories Inc. BIO ; , Hercules, Calif. Business: Diagnostic Deceased: Philip Padou Bradley Pharmaceuticals Inc. BDY ; , Fairfield, N.J. Business: Dermatology, Gastrointestinal Appointed: Leonard Jacob, former CEO of InKine Pharmaceuticals Co. Inc., as chairman; he replaces Daniel Glassman, who will remain president and CEO Celgene Corp. CELG ; , Summit, N.J. Business: Cancer, Neurology Appointed: James Loughlin Immunomedics Inc. IMMU ; , Morris Plains, N.J. Business: Autoimmune, Cancer, Antibodies Deceased: Richard Pivirotto InteKrin Therapeutics Inc., Palo Alto, Calif. Business: Endocrine, Metabolic Appointed: Jim Healy, general partner at Sofinnova Ventures; Sam Wertheimer, principal at OrbiMed Advisors LLC; and Barry Selick, CEO of Threshold Pharmaceuticals Inc. MDS Inc. TSX: MDS; MDZ ; , Toronto, Ontario Business: Supply Service Appointed: William Anderson, former president of Bell Canada Enterprises Ventures Inc. Movetis N.V., Vosselaar, Belgium Business: Gastrointestinal Appointed: Staf Van Reet, chairman of FlandersBio, as chairman; CEO Dirk Reyn; Antoine Papiernik, managing partner at Sofinnova Partners; Martijn Kleijwegt, managing partner at Life Sciences Partners; and Jim Healy, general partner at Sofinnova Ventures Napo Pharmaceuticals Inc. LSE: NAPL ; , South San Francisco, Calif. Business: Gastrointestinal Appointed: Mustapha Leavenworth Bakali, former COO of ID Biomedical Corp. Novexel S.A., Romainville, France Business: Infectious Appointed: Olivier Litzka, partner of life sciences at Edmond de Rothschild Investment Partners Progenics Pharmaceuticals Inc. PGNX ; , Tarrytown, N.Y. Business: Cancer, Infectious, Genitourinary Appointed: Nicole Williams, former EVP and CFO of Abraxis Bioscience Inc. Proprius Pharmaceuticals Inc., San Diego, Calif. Business: Autoimmune Appointed: Jean-Francois Formela, senior partner at Atlas Venture; Stuart Collinson, senior partner at Forward Ventures; and Nancy Olson, managing partner at Fog City Fund See next page.
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Ii ; provides a taxpayer identification number and certifies that no loss of exemption from backup withholding has occurred. Holders that are not U.S. persons generally are not subject to information reporting or backup withholding. However, such a holder may be required to provide a certification of its non-U.S. status in connection with payments received within the United States or through a U.S.-related financial intermediary. Backup withholding is not an additional tax. Amounts withheld as backup withholding may be credited against a holder's U.S. federal income tax liability. A holder may obtain a refund of any excess amounts withheld under the backup withholding rules by filing the appropriate claim for refund with the Internal Revenue Service and furnishing any required information. State and Local Taxes In addition to U.S. federal income tax, U.S. holders of Securities may be subject to U.S. state and local taxes with respect to such Securities. ADSs-Ordinary Shares French Taxes Taxation of Dividends As a result of both the reform implemented by the French Finance Bill for 2004 and the Finance Bill for 2006 No. 2005-1719 dated December 30, 2005 ; , French resident individuals will only be taxed on 60% of dividends received and, in addition to the annual allowance of 3, 050 for couples subject to joint taxation and 1, 525 for single persons, widowers or divorced persons which is already applicable, will be entitled to a tax credit equal to 50% of all dividends received within one year the "Tax Credit" ; . The Tax Credit is capped for all dividends received within one year at 230 for married couples and members of a union agreement subject to joint taxation and 115 for single persons, widows or widowers, divorced or married persons subject to separate taxation. Qualifying non-residents who were previously entitled to a refund of the avoir fiscal may benefit, under the same conditions as for the avoir fiscal, from a refund of the Tax Credit net of applicable withholding tax ; . The French tax authorities have not yet issued any guidance with regard to the applicable procedures to obtain a refund of the Tax Credit to non-residents. Under French law, dividends paid by a French corporation, such as sanofi-aventis, to non-residents of France are generally subject to French withholding tax at a rate of 25%. Under the Treaty, the rate of French withholding tax on dividends paid to a U.S. holder whose ownership of the ordinary shares or ADSs is not effectively connected with a permanent establishment or fixed base that such U.S. holder has in France is reduced to 15% and a U.S. holder may claim a refund from the French tax authorities of the amount withheld in excess of the Treaty rate of 15%, if any. In general, an eligible U.S. holder is a U.S. holder whose ownership of the ordinary shares or ADSs is not effectively connected with a permanent establishment or fixed base in France, and who is i ; an individual or other non-corporate person who is a U.S. resident, as defined pursuant to the provisions of the Treaty; ii ; a U.S. domestic corporation other than a "regulated investment company" iii ; a U.S. domestic corporation which is a "regulated investment company, " but only if less than 20% of its shares are beneficially owned by persons who are neither citizens nor residents of the United States; iv ; certain U.S. Pension Funds and Other Tax Exempt Entities as defined below or v ; a partnership or trust that is treated as a U.S. resident for purposes of the Treaty, but only to the extent that its partners, beneficiaries or grantors would qualify under clause i ; or ii ; above. Dividends paid to tax-exempt "U.S. Pension Funds" as discussed below, and certain other tax-exempt entities including certain State-owned institutions, not-for-profit organizations and individuals with respect to dividends beneficially-owned by such individuals and derived from an investment in a tax-favored retirement account "Other Tax-Exempt Entities" are nonetheless eligible for the reduced withholding tax rate of 15% provided for by the Treaty, subject to the filing formalities specified in the regulations discussed below ; , provided that these entities own, directly and indirectly, less than 10% of the capital of sanofi-aventis. A "U.S. Pension Fund" includes exempt pension funds subject to the provisions of Section 401 a ; qualified retirement plans ; , Section 403 b ; tax deferred annuity contract ; or Section 457 deferred compensation plans ; of the Code and which are established and managed in order to pay retirement benefits. 142!
Antecedent trauma or self-harm. The onset of bruising was often preceded by pain in the affected area. The pain was severe enough to wake her up on multiple occasions. As a result, she had been receiving intramuscular tramadol injections up to twice weekly on the buttocks from her local doctor. Other bruises resulting from trauma were asymptomatic. The bruises later extended to involve her lateral thighs. At this stage, the family doctor ceased the tramadol injections due to concerns of dependency and commenced her on intramuscular promethazine. This reportedly provided more effective relief for her pain. Multiple investigations had been carried out by other specialists before her presentation to dermatology outpatients. Haematological investigations revealed a prolonged activated partial thromboplastin time of 52 s 2542 s ; as a result of factor XII deficiency. Factor XII deficiency is not known to cause a bleeding or bruising tendency. On the contrary, there have been some reports of association with thromboembolic events, and possibly recurrent miscarriages.4, 5 Other investigations, as outlined in Table 1, were unremarkable. Imaging studies including computed tomography, ultrasound and bone scans of her left arm were all normal. Biopsy of a bruise on her left upper arm revealed moderate amounts of pigment-laden macrophages in a perivascular distribution within the deep dermis and subcutis regions, which stained positive for iron Fig. 1 ; . This is consistent with purpura. Apart from menorrhagia, the patient had no other prior history of excessive bleeding or bruising elsewhere. There had been no haemostatic complications with previous surgical procedures. Significant past medical history included left-sided breast carcinoma, bilateral mastectomy, hypertension, postoperative pulmonary embolism, recurrent miscarriages, depression resulting in a suicide attempt, anxiety and panic attacks. In addition, there was a history of vague paraesthesia in the right forearm, fibromyalgia, irritable bowel syndrome and recurrent migraines. Her medications included diazepam, amitriptyline, cyproheptadine hydrochloride, carbamazepine, metoprolol, eprosartan, prommethazine and nitrazepam. Multiple psychosocial stressors were present in the personal history. These included two failed marriages, alleged domestic violence and childhood sexual abuse. She revealed that the onset of bruising occurred around a time of conflict with her son. Collateral history also revealed abnormal and
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According to the Anatomical Therapeutic Chemical Classification Index of the World Health Organization9; The p values correspond to comparisons among age-strata chi-squared test NS not significant; Dipyrone, combination: 1 ampoule ; 500 mg dipyrone + 25 mg promeghazine + 25 mg adiphenine; Paracetamol, combination: 1 tablet ; 500 mg paracetamol + 7.5 mg or 30 mg codeine.
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