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The cardiovascular therapeutic area accounts for 33.2% of prescription pharmaceutical sales and is still the largest in our portfolio thanks mainly to the continuing success of lercanidipine and the launch of Rextat lovastatin ; , indicated for the treatment of hypercholesterolemia. Sales of Nitrocor, a nitroglycerin transdermal patch for the treatment of angina, were 4.7 million, in line with those recorded in 2005. In the CNS Central Nervous System ; area 25.3% of sales ; , Entact escitalopram ; , an SSRI antidepressant which is highly specific and selective and has an excellent tolerability profile, continues to perform well and has increased sales by 24.3%. Sales of Elopram citalopram ; , on the other hand, are decreasing due to competition from generic versions which resulted in a progressive price reduction. In the gastroenterological area 14.4% of sales ; , our main product is Peptazol pantoprazole ; , a proton pump inhibitor for the treatment of ulcers. Within the analgesia anti-inflammatory therapeutic area 11.8% of sales ; , Tora-Dol ketorolac ; maintains its position as the market leader in its class. At the end of 2005 the trademark and marketing authorization for this drug in Italy were acquired from the licensee Roche. Regarding the anti-infective area 11.3% of sales ; sales of Isocef ceftibuten ; and Octegra moxifloxacine ; , an antibacterial fluorquinolone, have decreased significantly with respect to 2005 in part due to a weak flu season. Sales of self-medication products in 2006 are 21.2 million, up 8.6% over the preceding year. Sales of Imidazyl and Proctolyn further increased during the year. Sales of AlovexTM, for the treatment of oral cavity aphthas, are up 34.5% to 3.6 million, consolidating its position as a reference product for this condition. Eumill, single dose eye drops, recorded increased sales and, together with Imidazyl, reinforces Recordati's leadership in the eye drops market. At the beginning of 2006 the Italian pharmaceuticals agency AIFA ; , after having reinstated the prices as at December 2004 of those products whose prices had been selectively reduced in 2005, imposed an across-the-board price reduction of 4.4% for reimbursed products as well as a mandatory discount to be applied by the pharmaceutical manufacturers of 1% with the aim to recover the 2005 expenditure which exceeded the established budget. On 21 June AIFA once again modified the list of reimbursable products by introducing selective price cuts for those drugs with above average performance during the first quarter of the year. The maximum price reduction was fixed at 10%. In addition, on 27 September a further 5% price reduction for all products reimbursed by the national healthcare scheme was imposed starting 1 October. All these measures will remain in place for the whole of 2007. However, at the beginning of 2007 AIFA decided to allow companies to chose, for the period 1 March 2007 to 29 February 2008, between maintaining the 5% price reduction or substituting it with an up-front payment of an amount equivalent to 5% of sales recorded in 2006. The option can be applied either to single products or to the whole product portfolio. Recordati opted to take advantage of this opportunity on a selective basis.
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This work was supported by a grant from the East Tennessee State University Research Development Committee to F. Levy and F. A. Sarubbi and a university noninstructional assignment to F. Levy. This material is the result of work supported with resources and the use of facilities at the James H. Quillen VA Medical Center, Mountain Home, Tenn. The experiments in this study comply with guidelines of the Institutional Review Board.
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Allergen-specific immunotherapy AIT ; is effective for the treatment of persons with seasonal rhinoconjunctivitis, especially patients with disease that responds poorly to anti-allergic pharmacotherapy.20 Recent studies suggest that AIT has immune modulatory effects beyond allergenspecific tolerance, and is relevant to airway allergic disease and asthma. Several studies have demonstrated that immunotherapy inhibits the early and late phase nasal responses after allergen provocation.20 In a recent study, evidence of a decrease in the nasal mucosal number of CD4 T-lymphocytes and total and activated eosinophils 24 hours after immunotherapy was presented.20 Furthermore, improvements in seasonal symptoms and medication requirements were associated with an increase in the expression of interferon IFN ; - in the allergen-stimulated nasal mucosa.20 This suggests that AIT may promote TH1 T-lymphocytes IFN- ; with downregulation of the effects of TH2 cytokines, resulting in the suppression of immunoglobulin Ig ; E and eosinophils.20 The effects of discontinuation of AIT for 3 to 4 years were also reported.21 Participants who had received active AIT remained in clinical remission for at least 3 years.21 Other studies have recently shown that AIT in children prevents additional sensitization to new aero-allergens "neo-sensitization" ; .22 A recent report also suggests that AIT in allergic rhinitis patients reduces the prevalence of new-onset asthma in these patients.23 These findings suggest that earlier AIT can prevent the progression or development of multiple allergen sensitizations and asthma through lasting immune-modulatory effects. An effort to improve AIT by combining it with mono and
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Escitalopram has no or very low affinity for serotonergic 5-ht1-7 ; or other receptors including and beta-adrenergic, dopamine d1-5 ; , histamine h1-3 ; , muscarinic m1-5 ; , benzodiazepine receptors and
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FIG. 7. Western blot and band-intensity analysis of AR and 3 subunit using total protein extracts from Ishikawa cells. The cells were treated without hormones Control [Con] ; or with DES 10 6 M ; , DES EGF 10 ng ml ; , DES DHT 10 6 M ; EGF, or EGF and DHT alone or in combination for 3 days. Note the increased expression of the 3 subunit protein in response to EGF treatment, which was either blocked or inhibited by treatment with any of the other steroid hormones used either alone or in combination. Expression of AR was increased by cotreatment with DES or with the combination of DES and DHT, and it was dramatically increased by DHT alone. Scanned band intensities were determined using the NIH Image 1.6 software program National Institutes of Health, Bethesda, MD ; on a Macintosh G3 computer Apple, Cupertino, CA.
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For each question there is only one best answer. 1. Which of the following is the least likely Congressional action in 2007? a. Elimination of the Part D benefit. b. Direct government negotiations with prescription drug manufacturers. c. Use of drug cost savings to fill the Medicare coverage gap i.e., "doughnut hole" ; . d. Simplification of PDP design and choice by offering a standard federal PDP. 2. Which of the following statements about the standard Medicare prescription drug benefit in 2007 is correct? a. It is the most popular choice among benefit designs for Medicare beneficiaries and
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Cancer is a physical disease but it also affects how you think and feel. You and your family friends might feel a range of emotions like fear, anxiety, anger, sadness, depression, loneliness or frustration ; related to your cancer diagnosis and treatment. This is understandable. Sometimes it is not possible to get all of the help and support you need from people closest to you. If you are having trouble coping with your cancer diagnosis, there are health care professionals at the Cancer Centre who can help such as psychologist, social worker, advanced practice nurse, spiritual care counselor, psychiatrist ; . As well, there are Support Groups you could attend, where you could talk with, or listen to, others who are going through a similar diagnosis and treatment. If you are interested in talking with someone about your feelings and experiences, tell the medical staff so they can connect you with the appropriate person or group. Your emotional health and well-being are very important.
Suffiering or who had suffered h m NVP voluntarily contacted an 'NVP Healthline' and were administered a questionnaire a s h about their experience with NVP. Women advised only to change their diet or lifestyle attributed an increased nsk for major malformations with antiemetics for NVP p 0 0 Wornen advised to take antiemetic .0 ; medication attributed no change in risk for major malformations with dmgs for NVP 0.002 ; . Sixty-six women reported elective termination of their pregnancy because of NVP. Casecontrol analysis identified 4 variables significantly associated w t elective temllnation: ih previous elective termination, unplannecl pregnancy, feelings of depression and lack of vitamin supplementation. Logistic regression analysis determined over 80% of the mode1 could be explained by these 4 factors and
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Enzyme pathway Trypanothione metabolism Evidence Validation of trypanothione reductase as a drug target suggested by genetic experiments. Glutathionylspermidine synthetase and trypanothione synthetase also potential targets yet to be fully validated. The Clan CA enzyme CPB validated by genetic manipulation and chemical means. Inhibitors of enzymes of sterol biosynthesis pathway e.g. 14 a-demethylase ; have antileishmanial activity in vitro. A favoured target as the enzyme differs from the mammalian counterpart and homologous enzymes are targets for the antimalarial pyrimethamine and the antibacterial trimethoprim. Enzyme inhibitors are promising agents in other chemotherapy e.g. as antifungals ; . Leishmanial NMT gene essential. Glycolysis considered essential, many enzymes enclosed in glycosomes. Ornithine decarboxylase is target of DFMO, an effective drug against African trypanosomiasis. Cyclin-dependent kinases essential to parasite. Tubulin validated as drug target. State of exploitation Many inhibitors of trypanothione reductase reported, yet none have been shown to be effective in vivo through inhibition of enzyme. Ref. [41].
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People who use benzodiazepines for insomnia often develop tolerance to the sleep-inducing effects within a few weeks of regular use; however, tolerance does not usually develop with occasional use. People who use benzodiazepines for anxiety rarely develop tolerance to the anxiety-relieving effects, and rarely increase their dose or lose control over their use of the drug. Tolerance to the effects of one type of benzodiazepine leads to tolerance to other benzodiazepines, and to other drugs with similar effects, including alcohol. People are said to be psychologically dependent when they have a strong craving for the effects of the drug, and feel compelled to take it, even when the drug does not produce the desired effects. Stopping use of benzodiazepines can be difficult for these people. People who are psychologically dependent may or may not also be physically dependent. People who are physically dependent will experience withdrawal symptoms if they stop using the drug abruptly.
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Asthma is a chronic inflammatory disorder of the airways that may cause recurrent episodes of wheezing, breathlessness, chest tightness and coughing. These episodes are typically associated with widespread but variable airflow obstruction that resolves spontaneously or with treatment. The inflammation of asthma may cause an increase in existing bronchial hyper-responsiveness to a variety of stimuli. Many cells and cellular elements play a role in asthma, including mast cells, eosinophils, T lymphocytes, macrophages, neutrophils and epithelial cells. Fibrosis may occur in some patients with asthma, resulting in persistent abnormalities in lung function. There is currently no direct measure of inflammation that is widely available clinically. Treatment decisions are therefore made based on indirect measures of inflammation, including symptoms scores, spirometry measures, rescue medication use, and or other indicators of disease activity. Analysis of exhaled nitric oxide has been proposed as a marker of inflammation that could be useful in monitoring disease activity and directing treatment in patients with asthma and other pulmonary conditions. Nitric oxide affects many organ systems, including the lungs, where it acts as a bronchodilator. Nitric oxide is.
Parsey, R.V., et al., Higher 5-HT 1A ; Receptor Binding Potential During a Major Depressive Episode Predicts Poor Treatment Response: Preliminary Data from a Naturalistic Study. Neuropsychopharmacology, 2006. 31 8 ; : 1745-9. Parsey, R.V., et al., Altered serotonin 1A binding in major depression: a [carbonyl-C11]WAY100635 positron emission tomography study. Biol Psychiatry, 2006. 59 2 ; : 106-13. Patel, J.G., et al., The highly selective 5-hydroxytryptamine 5-HT ; 2Areceptor antagonist, EMD 281014, significantly increases swimming and decreases immobility in male congenital learned helpless rats in the forced swim test. Synapse, 2004. 52 1 ; : 73-75. Paxinos, G., X. Huang, and A.W. Toga, The Rhesus monkey Brain in Stereotaxic Coordinates. 2000, San Diego: Academic Press. Pazos, A., A. Probst, and J.M. Palacios, Serotonin receptors in the human brain--III. Autoradiographic mapping of serotonin-1 receptors. Neuroscience, 1987. 21 1 ; : 97-122. Pazos, A., A. Probst, and J.M. Palacios, Serotonin receptors in the human brain--IV. Autoradiographic mapping of serotonin-2 receptors. Neuroscience, 1987. 21 1 ; : 123-139. Peroutka, S.J. and T.A. Howell, The molecular evolution of G protein-coupled receptors: Focus on 5-hydroxytryptamine receptors. Neuropharmacology, 1994. 33 3-4 ; : p. 319-324. Peroutka, S.J. and S.H. Snyder, Multiple Serotonin Receptors: Differential Binding of [3H]5Hydroxytryptamine, [3H]Lysergic Acid Diethylamide and [3H]Spiroperidol. Mol Pharmacol, 1979. 16 3 ; : 687-699. Perry, E., et al., Decreased imipramine binding in the brains of patients with depressive illness. Br J Psychiatry, 1983. 142 2 ; : p. 188-192. Pike, V.W., et al., First delineation of 5-HT1A receptors in human brain with PET and [11C]WAY-100635. Eur J Pharmacol, 1995. 283 1-3 ; : p. R1-3. Pike, V.W., et al., Exquisite delineation of 5-HT1A receptors in human brain with PET and [carbonyl-11 C]WAY-100635. Eur J Pharmacol, 1996. 301 1-3 ; : p. R5-7. Plenge, P., E.T. Mellerup, and H. Laursen, Regional distribution of the serotonin transport complex in human brain, identified with 3H-paroxetine, 3H-citalopram and 3H-imipramine. Prog Neuropsychopharmacol Biol Psychiatry, 1990. 14 1 ; : 61-72. Pompeiano, M., J. Palacios, and G. Mengod, Distribution and cellular localization of mRNA coding for 5-HT1A receptor in the rat brain: correlation with receptor binding. J. Neurosci., 1992. 12 2 ; : 440-453. Praschak-Rieder, N., et al., Effects of tryptophan depletion on the serotonin transporter in healthy humans. Biol Psychiatry, 2005. 58 10 ; : 825-30. Ramamoorthy, S., et al., Antidepressant- and Cocaine-Sensitive Human Serotonin Transporter: Molecular Cloning, Expression, and Chromosomal Localization. PNAS, 1993. 90 6 ; : 25422546. Rapport, M.M., A.A. Green, and I.H. Page, Serum vasoconstrictor Serotonin ; . IV. Isolation and characterization. J. Biol. Chem., 1948. 176 3 ; : p. 1243-1251. Redrobe, J.P. and M. Bourin, Dose-dependent influence of buspirone on the activities of selective serotonin reuptake inhibitors in the mouse forced swimming test. Psychopharmacology Berl ; , 1998. 138 2 ; : p. 198-206. Roberts, M.H.T., 5-Hydroxytryptamine and antinociception. Neuropharmacology, 1984. 23 12, Part 2 ; : p. 1529-1536. Ross, S.B. and A.L. Renyi, Accumulation of tritiated 5-hydroxytryptamine in brain slices. Life Sciences, 1967. 6 13 ; : 1407-1415. Sanchez, C., et al., Escitaolpram versus citalopram: the surprising role of the R-enantiomer. Psychopharmacology Berl ; , 2004. Sargent, P.A., et al., Brain serotonin1A receptor binding measured by positron emission tomography with [11C]WAY-100635: effects of depression and antidepressant treatment. Arch Gen Psychiatry, 2000. 57 2 ; : 174-80. Schechter, L.E., et al., Innovative approaches for the development of antidepressant drugs: current and future strategies. NeuroRx, 2005. 2 4 ; : 590-611. Schins, A., et al., Increased cerebral serotonin-2A receptor binding in depressed patients with myocardial infarction. Psychiatry Res, 2005. 139 2 ; : p. 155-63. Schlicker, E., et al., Anpirtoline, a novel, highly potent 5-HT1B receptor agonist with antinociceptive antidepressant-like actions in rodents. Br J Pharmacol, 1992. 105 3 ; : p. 732-8. Sheard, M.H., A. Zolovick, and G.K. Aghajanian, Rophe neurons: effect of tricyclic antidepressant drugs. Brain Res, 1972. 43 2 ; : 690-4.
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