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RATIONAL APPROACH TO GENETIC TESTING IN vWD The rationale for genetic testing of affected individuals can be summarized as follows. TYPE 1 VWD Genetic Testing of Affected Individuals. Genetic testing should not be performed as the initial screening test Figure 4 ; . Given its typically mild phenotype, the evolving state of knowledge of the molecular basis of type 1 vWD and the implication of locus heterogeneity, genetic testing of the proband for establishing the diagnosis of vWD is not currently recommended. Currently, genetic testing to differentiate patients with borderline reduced or borderline normal vWF levels from a normal state is not recommended. The role of testing for the presence or absence of Tyr1584Cys mutations remains to be defined.61 Further characterization of mutations found in pedigrees with vWD may aid in confirmation of the diagnosis but will not affect routine clinical management.21 Genetic Testing of At-Risk Family Members. Laboratory testing of potentially affected family members should consist of special coagulation testing vWD profile ; . Given the inconsistent genotype-phenotype correlation, genetic testing has no role as the initial screening test, even though the affected individuals in the family may have had a mutation identified.55 Prenatal Testing. In type 1 vWD, given the typically mild to moderate phenotype and complex issues related to genotype and phenotype correlation and finally the risks associated with the procedure, prenatal testing has no role. TYPE 3 VWD Genetic testing of families with type 3 vWD provides information that can significantly affect patient care; however, a critical appraisal of its utility is needed in each family Figure 5 ; . To address this, the following issues need to be considered: 1 ; do parents of the proband desire additional children; if they do 2 ; will they undergo prenatal testing; if they will 3 ; how will that information be used ie, will the parents desire termination of pregnancy if the fetus is found to be affected or is the information simply to know if the fetus is affected, which may assist in management of labor and delivery ; . For both possibilities, in experienced hands, fetal cord blood sampling may provide the information needed for both termination and management of the pregnancy, although chorionic villus sampling will permit an earlier diagnosis.48 For management of labor and delivery, unlike the case with severe hemophilia, 87 little is known about the risk of peripartum intracranial hemorrhage, but it seems to be low, for example, canada carisoprodol.
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Seminars Conferences held The Department organised an All India Seminar on 'Emerging Issues in Finance and Accounting Education and Research' under UGC-SAP ; on Feb. 26, 2005. Shri G.N. Bajpai, former Chairman, Securities and Exchange Board of India SEBI ; was the Guest of Honour. The Seminar was inaugurated by Shri P.K. Chaudhary, Managing Director, ICRA Ltd., and the Key Note address was delivered by Prof. L.C. Gupta, Director, Society for Capital Market Research and Development. The Department organised its Annual Convention on 'Indian Capital Market Vision2010 on 29th October 2004. Shri. Balasubramanian, Chairman, Company Law Board inaugurated the Convention. Shri S. Mukherji, Managing Director & CEO, ICICI Securities delivered the Key Note Address. The Department organised a panel discussion of Union Budget and Capital Markets on March 11, 2005. The speakers were Prof. I.M. Pandey, Professor of Finance, Indian Institute of Management, Ahemdabad, Dr. Vinod K. Singhania, Leading Tax Consultant, Shri Lalit Khanna, Chief Executive Officer, Escorts Mutual Funds. Seminars Conferences attended Dr. V.K. Vasal: Attended a Round Table on 'Expanding Corporate Governance, 3 December 2004 at Indian Institute of Management, Bangalore. Dr. Amitabh Gupta: Presented paper on "Mutual Funds: Agenda for Transparency and Disclosures" at two-day National Seminar on 'Corporate Governance: The 319 and clonidine!
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