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Positivity of protein bands in TB plasma for antigen S10 ranged from 12-77%. The maximum positivity was observed for 16 and 45kDa 77% ; followed by 38kDa 66% ; protein bands. The sonicate antigen S10 was found to be discriminatory by ELISA and Western blot and thus can be a good candidate for further purification of its individual proteins that needs to be evaluated for diagnosis. Identification of Target Genes devR-devS Two-Component System of M. tuberculosis M. tuberculosis is an intracellular pathogen that is remarkably well adapted to survival in the human host. Tubercle bacilli can remain dormant within tissue for decades and then cause reactivation disease when the immune system of the host is suppressed. A study was conducted at AIIMS, New Delhi with the objective of developing and establishing M. smegmatis non-pathogenic and rapid growing mycobacterial species ; as a suitable surrogate model to study the hypoxia response of M. tuberculosis and the involvement of DevR and dicyclomine.
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Landsgraf v. Columbia HCA Healthcare Corp. of Am., No. 3-98-0090, 2000 U.S. Dist. LEXIS 21831 M.D. Tenn. May 24, 2000 ; . 10 Lessard v. City of Allen Park, 372 F. Supp. 2d 1007 E.D. Mich. 2005 ; . 9 Mullane v. Central Hanover Bank & Trust Co., 339 U.S. 306 1950 ; . 21, 22 Officers for Justice v. Civil Serv. Comm'n. of S.F., 688 F.2d 615 9th Cir. 1982 ; . 14, 15 Reed v. Rhodes, 869 F. Supp. 1274 N.D. Ohio 1994 ; . 21, 22 Thompson, v. Midwest Found. Indep. Physicians Assoc., 124 F.R.D. 154 S.D. Ohio 1988 ; . 22 Van Horn v. Trickery, 840 F.2d 604 8th Cir. 1987 ; . 8 Weinberger v. Kendrick, 698 F.2d 61 2d Cir. 1982 ; . 22 Williams v. Vukovich, 720 F.2d 909 6th Cir. 1983 ; . passim Statutes ERISA 406 a ; , 29 U.S.C. 1106 a ; . 4 ERISA 409 a ; , 29 U.S.C. 1109 a ; . 12 Other Authorities Amended Brief of the Secretary of Labor As Amicus Curiae Opposing the Motions to Dismiss submitted in Tittle v. Enron Corp., Civil Action No. H-01-3913 S.D. Tex. Aug. 30, 2002 ; . 12 Manual for Complex Litig. 30.42 3d ed. 1995 ; . 9 Manual for Complex Litig. 30.44 2d ed. 1985 ; . 8, 9, 11 Newberg on Class Actions 11.51 3d ed. 1992 ; . 20 Newberg on Class Actions 8.34 4th Ed. 2002 ; . 22 Restatement Second ; of Trusts 205 c ; 1959 ; . 12 Rules Fed. R. Civ. P. 23 . 7, Fed. R. Civ. P. 23 e ; INTRODUCTION The Class Representatives, by and through their counsel, respectfully move the Court for an Order granting preliminary approval of the Settlement Agreement described herein. The Settlement Agreement, which provides a cash payment of $28 million plus interest and nonmonetary equitable relief regarding the administration and management of the Plan, is an excellent recovery for the Employees' Savings Plan of Consumers Energy Company the "Plan" ; and the Class, and resolves the claims against all of the Defendants in this ERISA action. The Settlement, by its express terms, does not release, bar, waive, or otherwise affect the claims asserted in the pending securities action, In re CMS Energy Securities Litigation, Master File No. 02-CV-72004. The Settlement Agreement was reached after vigorous motions practice, extensive discovery, and arm's length negotiations. It will provide significant benefits to the Class, while removing the risk and delay associated with further litigation. Plaintiffs request that the Court grant their motion so that the Class may obtain the substantial benefits provided by the Settlement Agreement. II. BACKGROUND FACTS A. Procedural And Litigation History. The Court is familiar with the case as a result of the extensive briefing on the motions to dismiss and the Plaintiffs' motion for class certification. In brief, on December 19, 2003, Plaintiffs filed the Consolidated Amended Complaint for Breach of Fiduciary Duty under ERISA "Complaint" ; in this action. Defendants subsequently filed extensive motions to and clarithromycin, for example, bentyl interactions.
In this next set of questions, I will ask about injuries that may have happened to child's name ; in the past 3 months. CH100. During the past three months, that is since [fill 91 days before today's date], was child's name ; injured seriously enough that he she ; got medical advice or treatment, missed school, or remained in bed for at least half a day because of an injury? 1 2 7 Yes No Go to CH104 Don't know Not sure Go to CH104 Refused Go to CH104.
Candace J. Majeski; 1 Gilles J. Lauzon; 1 Jeffrey A. Johnson; 2 Sara N. Davison; 3 1 Division of Dermatology, University of Alberta, Edmonton, AB, Canada 2 Department of Public Health Sciences, University of Alberta, Edmonton, AB, Canada 3 Division of Nephrology, University of Alberta, Edmonton, AB, Canada Introduction: Pruritus, a common symptom in dermatology, is associated with psychiatric morbidity, sleep disturbances, and an overall reduced health-related quality of life HRQL ; . Assessing its severity is difficult because of its subjective nature. Recently developed questionnaires do not specifically quantify pruritus severity. A questionnaire that takes into account how the symptom is perceived by the patient may provide a more accurate representation of the pruritus. Methods: An instrument for the characterization and evaluation of pruritus developed by Yosipovitch and colleagues was modified to be in self-report format and completed, along with the RAND-36 and Dermatology Life Quality Index DLQI ; , by 93 patients with pruritus associated with their chronic plaque psoriasis. Exploratory factor analysis, studies of internal consistency, inter-item correlation analyses, and correlation analyses with HRQL scores were used to help determine which components of the instrument to include in the Itch Severity Scale ISS ; . The final ISS was then assessed for construct validity, internal consistency reliability, and test-retest reliability. Results and Conclusions: The ISS includes questions on frequency of pruritus, intensity, body surface area involved, a description of pruritus sensation, affective descriptors, and questions on how pruritus affects sleep, mood, ability to concentrate, sexual desire, and sexual function. ISS scores correlated moderately with physical r -.483 ; and mental r -.492 ; health composite scores of the RAND-36 and correlated strongly with DLQI scores r .628 ; , indicating good construct validity. It had an internal consistency reliability of .80 and a test-retest reliability of .95. Overall, the ISS is the first questionnaire for the quantification of pruritus severity. Results provide solid preliminary evidence of its validity and reliability. Such an instrument may be useful in comparing pruritus severity among different disease populations, in determining the effect of pruritus severity on HRQL, or in assessing pruritus treatment effectiveness and brethine.
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Hideaki Katagiri, Takuji Fukumoto, Go Okada, Masayo Sawa, Terufumi Nakahara, Soichi Mizuno, Mitsutaro Muraoka Mihara Hospital, Hiroshima, Japan ; purpose ; It is thought that the tolerance to antipsychotics in elderly patients with shizoprenia is decreased. Therefore we investigated the situation of prescription to elderly patients with schizophrenia in our hospital. methods ; A survey on drug prescriptions in inpatients with schizophrenia elder than 65 years old was carried out on one day every two years among 2006 from 1998. The daily doses of antipsychotic medications converted to chlorpromazine equivalents and anticholinergic medications converted to biperiden equivalents were investigated. result ; The daily doses of antipsychotics were not changed among 2006 from 1998 [an average of chlorpromazine equivalents, 1998: 466mg day, 2000: 453mg day, 2002: 449mg day, 2004: 488mg day, 2006: 430.4mg day]. But the daily doses of anticholinergic medications were significantly degreased among 2006 from 1998 [an average of biperiden equivalents, 1998: 2.7mg day, 2000: 2.3mg day, 2002: 1.7mg day, 2004: 1.3mg day, 2006: 1.1mg day]. The uses of second-generation antipsychotics were gradually increased among 2006 from 1998 [a rate of patients received second-generation antipsychotics, 1998: 7.9%, 2000: conclusion ; The daily doses of anticholinergic medications to elder patients with schizophrenia were decreased without changes of the daily doses of antipsychotics. This was related to the increases of use of second-generation antipsychotics and
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Dany Anglicheau was awarded a grant by the Groupe Cooperatif d'Ile-de-France. This work was supported by the Delegation a la ` Recherche Clinique-Hopitaux de Paris and by the Institut National de la Sante et de la Recherche Medicale. The funding sources were not involved in study design; the collection, analysis, and interpretation of data; or the writing of this report and terbutaline.
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P .029 ; , anxiety p .02 ; , depression p .006 ; , paranoia p .001 ; , and borderline features p .048 ; , but no significant increase in anxiety related disorders, mania, schizophrenic or antisocial features, alcohol or drug problems, aggression, suicidal ideation, perception of stress, perceived social support, treatment rejection, dominance, or warmth. These increased levels of symptoms, while statistically significant, were still within normal limits for the population. Conclusion : Prolonged wakefulness of 56 hours was associated with a statistically significant, though not clinically pathological increase in selfreported symptoms of psychopathology. The greater affective dysregulation may be the result of the reduced prefrontal metabolic activity associated with sleep deprivation. Support optional and
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Among the 330 doctors who completed the survey, the number one reason for prescribing an NSAID of any type was musculoskeletal pain. For COX-2s, the number one reason was arthritis. The study, led by Deborah M. Levy, MD, chair of the Executive Committee of the Pediatric Section of the American College of Rheumatology and a pediatric rheumatologist at Columbia University Medical Center, shows that most doctors perceive NSAIDs, including COX-2s, to be safe in kids. Almost half 42 percent ; of the respondents said they believed COX-2s to be as safe as traditional NSAIDs and nearly a quarter 24 percent ; considered them safer. More than half 52 percent ; believed the COX-2s were as effective at traditional NSAIDs at relieving pain, and 20 percent believed them to be more effective for pain relief. Fifty-nine percent believed they were equally effective against inflammation, and 15 found COX-2s to be more effective. The majority 83 percent ; believed COX-2s were equal to or better than traditional NSAIDs in terms of tolerability. Doctors surveyed listed things stopping them from prescribing a COX-2 include lack of testing in children, lack of it being in liquid form and parents not wanting their child to take it. Side effects doctors reported seeing occasionally or frequently among NSAID users were generally less common with COX-2s and included abdominal pain, gastric ulcers, blood in the urine, hyper.
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It's important for you to know that the information we present here is not meant to substitute for a doctor's judgment. But we hope it will help your doctor and you arrive at a decision about whether you need an Alzheimer's drug and, if so, which one is best for you. Bear in mind that many people are reluctant to discuss the cost of medicines with their doctors and that studies show doctors do not routinely take price into account when prescribing medicines. Unless you bring it up, your doctors may assume that cost is not a factor for you. Many people including many physicians ; also believe that newer drugs are always or almost always better. While that's a natural assumption to make, the fact is that it's not true. Studies consistently show that many older medicines are as good as, and in some cases better than, newer medicines. Think of them as "tried and true, " particularly when it comes to their safety record. Newer drugs have not yet met the test of time, and unexpected problems can and do crop up once they hit the market. Of course, some newer prescription drugs are indeed more effective and safer. Talk with your doctor about the pluses and minuses of newer versus older medicines, including generic drugs. Prescription medicines go "generic" when a company's patents on a drug lapse, usually after about 12 to 15 years. At that point, other companies can make and sell the drug. Generics are almost always much less expensive than newer brand name medicines, but they are not lesser quality drugs. Indeed, most generics remain useful medicines even many years after first being marketed. That is why today about half of all prescriptions in the U.S. are for generics. Another important issue to talk with your doctor about is keeping a record of the drugs you are taking. There are several reasons for this: First, if you see several doctors, they may not always tell each other which drugs have been prescribed for you. Second, it is very common for doctors today to prescribe several medicines for you before finding one that works well or best, mostly because people vary in their response to prescription drugs. Third, more and more people today take several prescription medications, nonprescription drugs and supplements all at the same time. Many of these interact in ways that can be very dangerous. And fourth, the names of prescription drugs--both generic and brand--are often hard to pronounce and remember. For all these reasons, it's important to keep a list of the drugs you are taking, both prescription and nonprescription and including dietary supplements. Always be sure, too, that you understand the dose of the medicine being prescribed for you and how many pills you are expected to take each day. Your doctor should tell you this information. When you fill a prescription at the pharmacy, or if you get it by mail, you may want to check to see that the dose and the number of pills per day on the pill bottle match the amounts that your doctor told you.
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Your patients may be eager to self-medicate with nutritional supplements that offer hope. Over 60% of Parkinson's disease patients use nutritional supplements. Less than half of them report this to their doctors AAN, 2006c ; . This is a practice that is not only expensive but may be dangerous because of potential drug interactions Brandabur, 2004 ; . Encourage your patients to disclose their experimentation with alternative treatments by assuming a nonjudgmental attitude.
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What it measures B Perceived disability in the areas of sleep, eating, home management, recreation, mobility, body care, social interaction, emotional behavior, and communication. Benefits B Assesses a broad spectrum of patient disability reports. Serial administrations could be used to track patient perceived functional changes during the course of treatment, and assess outcome. F ; McGill Pain Questionnaire MPQ ; What it measures B Cognitive, emotional and sensory aspects of pain. Benefits B Can identify patients prone to pain magnification. Repeated administrations can track progress in treatment for pain. G ; McGill Pain Questionnaire B Short Form MPQ-SF ; What it measures B Emotional and sensory aspects of pain. Benefits B Can identify patients prone to pain magnification. Repeated administrations can track progress in treatment for pain. H ; Oswestry Disability Questionnaire What it measures B Disability secondary to low back pain. Benefits B Can measure patients self-perceptions of disability. Serial administrations could be used to track changes in selfperceptions of functional ability during the course of treatment, and assess outcome. I ; Visual Analog Scales VAS ; What it measures B Graphical measure of patient s pain report. Benefits B Quantifies the patients pain report. Serial administrations could be used to track changes in pain reports during the course of treatment and assess outcome. iv. Brief Multidimensional Screens for Psychiatric Patients These tests are designed for detecting various psychiatric syndromes, but in general are more prone to false positive findings when administered to medical patients. A ; Brief Symptom Inventory, for instance, bentyl and ibs.
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